serval:BIB_5A75094A411B
Beta-catenin is dispensable for hematopoiesis and lymphopoiesis.
10.1084/jem.20031615
000188369700008
14718516
Cobas
M.
author
Wilson
A.
author
Ernst
B.
author
Mancini
S.J.
author
MacDonald
H.R.
author
Kemler
R.
author
Radtke
F.
author
article
2004
The Journal of experimental medicine
0022-1007
journal
199
2
221-229
Beta-catenin-mediated Wnt signaling has been suggested to be critically involved in hematopoietic stem cell maintenance and development of T and B cells in the immune system. Unexpectedly, here we report that inducible Cre-loxP-mediated inactivation of the beta-catenin gene in bone marrow progenitors does not impair their ability to self-renew and reconstitute all hematopoietic lineages (myeloid, erythroid, and lymphoid), even in competitive mixed chimeras. In addition, both thymocyte survival and antigen-induced proliferation of peripheral T cells is beta-catenin independent. In contrast to earlier reports, these data exclude an essential role for beta-catenin during hematopoiesis and lymphopoiesis.
Animals
B-Lymphocytes/cytology
B-Lymphocytes/immunology
Cell Differentiation
Cell Division
Chimera
Cytoskeletal Proteins/deficiency
Cytoskeletal Proteins/genetics
Female
Hematopoiesis/genetics
Hematopoiesis/physiology
Integrases/genetics
Lymphopoiesis/genetics
Lymphopoiesis/physiology
Mice
Mice, Inbred C57BL
Mice, Knockout
Phenotype
Proto-Oncogene Proteins/genetics
Proto-Oncogene Proteins/physiology
Signal Transduction
T-Lymphocytes/cytology
T-Lymphocytes/immunology
Trans-Activators/deficiency
Trans-Activators/genetics
Wnt Proteins
beta Catenin
eng
60_published
true
peer-reviewed
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
University of Lausanne
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