serval:BIB_4E7C776F2378
Associations Between Presenting Symptoms, Clinicopathological Parameters, and Prognosis in a Contemporary Series of Patients With Renal Cell Carcinoma
10.4111/kju.2014.55.8.505
25132943
Hofbauer
S.L.
author
de Martino
M.
author
Seemann
C.
author
Zamani
N.
author
Lucca
I.
author
Haitel
A.
author
Shariat
S.F.
author
Klatte
T.
author
article
2014
Korean Journal of Urology
2005-6737
2005-6745
2005-6737
journal
55
8
505-510
PURPOSE: To evaluate the impact of presenting symptoms on survival in a contemporary series of patients with renal cell carcinoma (RCC).
MATERIALS AND METHODS: We prospectively recorded data on the presenting symptoms, pathology, and RCC-specific survival of 633 consecutive RCC patients who underwent surgery between 2003 and 2012.
RESULTS: Four hundred thirty-three RCCs (68%) were incidental, 111 (18%) were associated with local symptoms, and 89 (14%) were associated with systemic symptoms. Among those with incidental RCC, 317 patients (73%) were completely asymptomatic and 116 patients (27%) presented with symptoms not related to the tumor. During a median follow-up interval of 40 months (interquartile range: 39 to 69 months), 77 patients died from RCC. In univariate analyses, symptom classification was significantly associated with RCC-specific survival (p<0.001). Patients with incidental RCC and unrelated symptoms tended to have worse prognosis than did patients who were completely asymptomatic, although this difference was not statistically significant (p=0.057). The symptom classification was associated with advanced TNM stages (p<0.001) and grade (p<0.001).
CONCLUSIONS: This study confirms that presenting symptoms are associated with tumor characteristics and survival. The majority of RCCs are diagnosed incidentally in patients without any symptoms or with symptoms not related to RCC. Patients in the latter group tend to have a worse prognosis than do patients who are completely asymptomatic. With the increasing number of incidentally diagnosed RCCs, substratification of patients with incidental tumors may be prognostically relevant.
Carcinoma, Renal Cell/diagnosis
Carcinoma, Renal Cell/pathology
Carcinoma, Renal Cell/surgery
Kidney Neoplasms/diagnosis
Kidney Neoplasms/pathology
Kidney Neoplasms/surgery
Nephrectomy/methods
eng
60_published
true
peer-reviewed
Publication types: Original Article ; research-article Identifiant PubMed Central: PMC4131077
University of Lausanne
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