serval:BIB_4E657C258D0B
Senescence in cell oxidative status in two bird species with contrasting life expectancy.
10.1007/s00442-013-2840-3
000333171400003
24292795
Bize
P.
author
Cotting
S.
author
Devevey
G.
author
van Rooyen
J.
author
Lalubin
F.
author
Glaizot
O.
author
Christe
P.
author
article
2014
Oecologia
1432-1939
0029-8549
journal
174
4
1097-1105
Oxidative stress occurs when the production of reactive oxygen species (ROS) by an organism exceeds its capacity to mitigate the damaging effects of the ROS. Consequently, oxidative stress hypotheses of ageing argue that a decline in fecundity and an increase in the likelihood of death with advancing age reported at the organism level are driven by gradual disruption of the oxidative balance at the cellular level. Here, we measured erythrocyte resistance to oxidative stress in the same individuals over several years in two free-living bird species with contrasting life expectancy, the great tit (known maximum life expectancy is 15.4 years) and the Alpine swift (26 years). In both species, we found evidence for senescence in cell resistance to oxidative stress, with patterns of senescence becoming apparent as subjects get older. In the Alpine swift, there was also evidence for positive selection on cell resistance to oxidative stress, the more resistant subjects being longer lived. The present findings of inter-individual selection and intra-individual deterioration in cell oxidative status at old age in free-living animals support a role for oxidative stress in the ageing of wild animals.
eng
60_published
true
peer-reviewed
University of Lausanne
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