serval:BIB_454F8ACC0454
Progressive decline of decision-making performances during multiple sclerosis.
10.1017/S1355617709090262
000263961100014
19203433
Simioni
S.
author
Ruffieux
C.
author
Kleeberg
J.
author
Bruggimann
L.
author
du Pasquier
R.A.
author
Annoni
J.M.
author
Schluep
M.
author
article
2009
Journal of the International Neuropsychological Society
1469-7661[electronic]
journal
15
2
291-295
The purpose of this study was to evaluate longitudinally, using the Iowa Gambling Task (IGT), the dynamics of decision-making capacity at a two-year interval (median: 2.1 years) in a group of patients with multiple sclerosis (MS) (n = 70) and minor neurological disability [Expanded Disability Status Scale (EDSS) < or = 2.5 at baseline]. Cognition (memory, executive functions, attention), behavior, handicap, and perceived health status were also investigated. Standardized change scores [(score at retest-score at baseline)/standard deviation of baseline score] were computed. Results showed that IGT performances decreased from baseline to retest (from 0.3, SD = 0.4 to 0.1, SD = 0.3, p = .005). MS patients who worsened in the IGT were more likely to show a decreased perceived health status and emotional well-being (SEP-59; p = .05 for both). Relapsing rate, disability progression, cognitive, and behavioral changes were not associated with decreased IGT performances. In conclusion, decline in decision making can appear as an isolated deficit in MS.
Adult
Decision Making
Disability Evaluation
Disease Progression
Female
Humans
Longitudinal Studies
Male
Middle Aged
Multiple Sclerosis
Neuropsychological Tests
Young Adult
eng
60_published
true
peer-reviewed
University of Lausanne
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