serval:BIB_3B38B04B8D47
Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription.
10.1126/science.1242463
24136355
000326647600045
Kilpinen
H.
author
Waszak
S.M.
author
Gschwind
A.R.
author
Raghav
S.K.
author
Witwicki
R.M.
author
Orioli
A.
author
Migliavacca
E.
author
Wiederkehr
M.
author
Gutierrez-Arcelus
M.
author
Panousis
N.I.
author
Yurovsky
A.
author
Lappalainen
T.
author
Romano-Palumbo
L.
author
Planchon
A.
author
Bielser
D.
author
Bryois
J.
author
Padioleau
I.
author
Udin
G.
author
Thurnheer
S.
author
Hacker
D.
author
Core
L.J.
author
Lis
J.T.
author
Hernandez
N.
author
Reymond
A.
author
Deplancke
B.
author
Dermitzakis
E.T.
author
article
2013
Science
1095-9203
0036-8075
journal
342
6159
744-747
DNA sequence variation has been associated with quantitative changes in molecular phenotypes such as gene expression, but its impact on chromatin states is poorly characterized. To understand the interplay between chromatin and genetic control of gene regulation, we quantified allelic variability in transcription factor binding, histone modifications, and gene expression within humans. We found abundant allelic specificity in chromatin and extensive local, short-range, and long-range allelic coordination among the studied molecular phenotypes. We observed genetic influence on most of these phenotypes, with histone modifications exhibiting strong context-dependent behavior. Our results implicate transcription factors as primary mediators of sequence-specific regulation of gene expression programs, with histone modifications frequently reflecting the primary regulatory event.
eng
60_published
University of Lausanne
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