serval:BIB_31178C23B5D8
Myeloid-Derived Suppressor Cells in Sepsis.
10.3389/fimmu.2019.00327
000459765100001
30873175
Schrijver
I.T.
author
Théroude
C.
author
Roger
T.
author
article
review
2019
Frontiers in immunology
1664-3224
1664-3224
journal
10
327
Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells characterized by their immunosuppressive functions. MDSCs expand during chronic and acute inflammatory conditions, the best described being cancer. Recent studies uncovered an important role of MDSCs in the pathogenesis of infectious diseases along with sepsis. Here we discuss the mechanisms underlying the expansion and immunosuppressive functions of MDSCs, and the results of preclinical and clinical studies linking MDSCs to sepsis pathogenesis. Strikingly, all clinical studies to date suggest that high proportions of blood MDSCs are associated with clinical worsening, the incidence of nosocomial infections and/or mortality. Hence, MDSCs are attractive biomarkers and therapeutic targets for sepsis, especially because these cells are barely detectable in healthy subjects. Blocking MDSC-mediated immunosuppression and trafficking or depleting MDSCs might all improve sepsis outcome. While some key aspects of MDSCs biology need in depth investigations, exploring these avenues may participate to pave the way toward the implementation of personalized medicine and precision immunotherapy for patients suffering from sepsis.
Biomarkers
Disease Susceptibility
Granulocytes/immunology
Granulocytes/metabolism
Host-Pathogen Interactions/immunology
Humans
Immune Tolerance
Immunity, Innate
Immunomodulation
Myeloid-Derived Suppressor Cells/immunology
Myeloid-Derived Suppressor Cells/metabolism
Prognosis
Sepsis/diagnosis
Sepsis/etiology
Sepsis/metabolism
Sepsis/mortality
biomarker
immunosuppression
infectious disease
inflammation
innate immunity
myeloid-derived suppressor cells
personalized medicine
sepsis
eng
60_published
true
peer-reviewed
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: epublish
University of Lausanne
mailto:serval_help@unil.ch
http://www.unil.ch/serval
http://serval.unil.ch/disclaimer
https://serval.unil.ch/notice/serval:BIB_31178C23B5D8