serval:BIB_2C6527444F7B
Synchronous tumors of the pancreas and the gallbladder: a case report with targeted NGS evaluation.
10.21037/atm.2019.10.107
000500459400086
31930097
Sivade
A.
author
Sempoux
C.
author
Voutsadakis
I.
author
Brunel
C.
author
Halkic
N.
author
Godat
S.
author
Duran
R.
author
Digklia
A.
author
article
2019-11
Annals of translational medicine
2305-5839
2305-5839
journal
7
22
696
Synchronous tumors of the pancreas and gallbladder are rare and often attributed to an abnormal pancreato-biliary junction, which results in a persistent reflux of pancreatic secretions leading to chronic biliary inflammation. We present the case of a 73-year-old woman with synchronous lesions of the pancreas and gallbladder initially considered as two primary localized cancers and treated with curative intent. At relapse, targeted next generation sequencing (NGS), performed in search of potential therapeutic targets, uncovered the fact that the two lesions appeared to be clonally related. This case illustrates the problem of synchronous lesions of the pancreas and gallbladder. New pathologic assessments with comparative molecular analysis of mutational profiles may be helpful in this context.
HER2
Next generation sequencing (NGS)
cancer
gallbladder
eng
60_published
true
peer-reviewed
Publication types: Case Reports
Publication Status: ppublish
University of Lausanne
mailto:serval_help@unil.ch
http://www.unil.ch/serval
http://serval.unil.ch/disclaimer
https://serval.unil.ch/notice/serval:BIB_2C6527444F7B