serval:BIB_2314A746CDE2
Higher memory responses in HIV-infected and kidney transplanted patients than in healthy subjects following priming with the pandemic vaccine.
10.1371/journal.pone.0040428
000306950200020
22848378
Siegrist
C.A.
author
van Delden
C.
author
Bel
M.
author
Combescure
C.
author
Delhumeau
C.
author
Cavassini
M.
author
Clerc
O.
author
Meier
S.
author
Hadaya
K.
author
Soccal
P.M.
author
Yerly
S.
author
Kaiser
L.
author
Hirschel
B.
author
Calmy
A.
author
H1N1 Study Group
contributor
Swiss HIV Cohort Study (SHCS)
contributor
Siegrist
CA.
contributor
Posfay-Barbe
K.
contributor
Meier
S.
contributor
Bel
M.
contributor
Grillet
S.
contributor
Sealy
G.
contributor
Demeules
J.
contributor
Charvat
S.
contributor
Verdon
M.
contributor
Combescure
C.
contributor
Hirschel
B.
contributor
Calmy
A.
contributor
Delhumeau-Cartier
C.
contributor
Gabay
C.
contributor
Guerne
PA.
contributor
Seebach
J.
contributor
Ribi
C.
contributor
Villard
J.
contributor
Dietrich
PY.
contributor
George
AC.
contributor
Favet
L.
contributor
van Delden
C.
contributor
Morard
I.
contributor
Mentha
G.
contributor
Giostra
E.
contributor
Hadaya
K.
contributor
Martin
PY.
contributor
Soccal
P.
contributor
Berney
T.
contributor
Noble
S.
contributor
Mohty
B.
contributor
Nagy
M.
contributor
Chalandon
Y.
contributor
Roosnek
E.
contributor
Passweg
J.
contributor
Kaiser
L.
contributor
Yerly
S.
contributor
Thomas
Y.
contributor
Wunderli
W.
contributor
Barth
J.
contributor
Battegay
M.
contributor
Bernasconi
E.
contributor
Böni
J.
contributor
Bucher
HC.
contributor
Burton-Jeangros
C.
contributor
Calmy
A.
contributor
Cavassini
M.
contributor
Cellerai
C.
contributor
Egger
M.
contributor
Elzi
L.
contributor
Fehr
J.
contributor
Fellay
J.
contributor
Flepp
M.
contributor
Francioli
P.
contributor
Furrer
H.
contributor
Fux
CA.
contributor
Gorgievski
M.
contributor
Günthard
H.
contributor
Haerry
D.
contributor
Hasse
B.
contributor
Hirsch
HH.
contributor
Hirschel
B.
contributor
Hösli
I.
contributor
Kahlert
C.
contributor
Kaiser
L.
contributor
Keiser
O.
contributor
Kind
C.
contributor
Klimkait
T.
contributor
Kovari
H.
contributor
Ledergerber
B.
contributor
Martinetti
G.
contributor
Martinez de Tejada
B.
contributor
Metzner
K.
contributor
Müller
N.
contributor
Nadal
D.
contributor
Pantaleo
G.
contributor
Rauch
A.
contributor
Regenass
S.
contributor
Rickenbach
M.
contributor
Rudin
C.
contributor
Schmid
P.
contributor
Schultze
D.
contributor
Schöni-Affolter
F.
contributor
Schüpbach
J.
contributor
Speck
R.
contributor
Taffé
P.
contributor
Tarr
P.
contributor
Telenti
A.
contributor
Trkola
A.
contributor
Vernazza
P.
contributor
Weber
R.
contributor
Yerly
S.
contributor
article
2012
Plos One
1932-6203
1932-6203
journal
7
7
e40428
BACKGROUND: Memory responses require immune competence. We assessed the influence of priming with AS03-adjuvanted pandemic vaccine (Pandemrix®) on memory responses of HIV patients, kidney recipients (SOT) and healthy controls (HC).
METHOD: Participants (HIV: 197, SOT: 53; HC: 156) were enrolled in a prospective study and 390/406 (96%) completed it. All had been primed in 2009/2010 with 1 (HC) or 2 (patients) doses of Pandemrix®, and were boosted with the 2010/2011 seasonal influenza vaccine. Geometric mean titres and seroprotection rates were measured 12 months after priming and 4 weeks after boosting. Primary and memory responses were directly compared in 191 participants (HCW: 69, HIV: 71, SOT: 51) followed during 2 consecutive seasons.
RESULTS: Most participants (HC: 77.8%, HIV: 77.6%, SOT: 66%) remained seroprotected at 12 months post-priming. Persisting A/09/H1N1 titers were high in HIV (100.2) and HC (120.1), but lower in SOT (61.4) patients. Memory responses reached higher titers in HIV (507.8) than in HC (253.5) and SOT (136.9) patients. Increasing age and lack of HAART reduced persisting and memory responses, mainly influenced by residual antibody titers. Comparing 2009/2010 and 2010/2011 titers in 191 participants followed for 2 seasons indicated lower post-2010/2011 titers in HC (240.2 vs 313.9), but higher titers in HIV (435.7 vs 338.0) and SOT (136 vs 90.3) patients.
CONCLUSIONS: Priming with 2 doses of Pandemrix® elicited persistent antibody responses and even stronger memory responses to non-adjuvanted seasonal vaccine in HIV patients than 1 dose in healthy subjects. Adjuvanted influenza vaccines may improve memory responses of immunocompromised patients.
TRIAL REGISTRATION: ClinicalTrials.gov NCT01022905.
Adult
Aged
Antibodies, Viral/blood
Antibodies, Viral/immunology
Female
HIV Infections/blood
HIV Infections/immunology
Humans
Immunocompromised Host
Immunologic Memory/drug effects
Influenza Vaccines/administration & dosage
Influenza, Human/blood
Influenza, Human/immunology
Kidney Transplantation/immunology
Male
Middle Aged
Pandemics
eng
60_published
true
peer-reviewed
Publication types: Clinical Trial ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
University of Lausanne
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