serval:BIB_219E56C424E8
Multi-channel MRI segmentation of eye structures and tumors using patient-specific features.
10.1371/journal.pone.0173900
000399174400009
28350816
Ciller
C.
author
De Zanet
S.
author
Kamnitsas
K.
author
Maeder
P.
author
Glocker
B.
author
Munier
F.L.
author
Rueckert
D.
author
Thiran
J.P.
author
Bach Cuadra
M.
author
Sznitman
R.
author
article
2017
PloS one
1932-6203
1932-6203
journal
12
3
e0173900
Retinoblastoma and uveal melanoma are fast spreading eye tumors usually diagnosed by using 2D Fundus Image Photography (Fundus) and 2D Ultrasound (US). Diagnosis and treatment planning of such diseases often require additional complementary imaging to confirm the tumor extend via 3D Magnetic Resonance Imaging (MRI). In this context, having automatic segmentations to estimate the size and the distribution of the pathological tissue would be advantageous towards tumor characterization. Until now, the alternative has been the manual delineation of eye structures, a rather time consuming and error-prone task, to be conducted in multiple MRI sequences simultaneously. This situation, and the lack of tools for accurate eye MRI analysis, reduces the interest in MRI beyond the qualitative evaluation of the optic nerve invasion and the confirmation of recurrent malignancies below calcified tumors. In this manuscript, we propose a new framework for the automatic segmentation of eye structures and ocular tumors in multi-sequence MRI. Our key contribution is the introduction of a pathological eye model from which Eye Patient-Specific Features (EPSF) can be computed. These features combine intensity and shape information of pathological tissue while embedded in healthy structures of the eye. We assess our work on a dataset of pathological patient eyes by computing the Dice Similarity Coefficient (DSC) of the sclera, the cornea, the vitreous humor, the lens and the tumor. In addition, we quantitatively show the superior performance of our pathological eye model as compared to the segmentation obtained by using a healthy model (over 4% DSC) and demonstrate the relevance of our EPSF, which improve the final segmentation regardless of the classifier employed.
Algorithms
Cornea/anatomy & histology
Cornea/diagnostic imaging
Eye/anatomy & histology
Eye/diagnostic imaging
Eye Neoplasms/diagnostic imaging
Eye Neoplasms/pathology
Humans
Imaging, Three-Dimensional/methods
Lens, Crystalline/diagnostic imaging
Magnetic Resonance Imaging/methods
Models, Anatomic
Sclera/anatomy & histology
Sclera/diagnostic imaging
Vitreous Body/anatomy & histology
Vitreous Body/diagnostic imaging
eng
60_published
true
peer-reviewed
Publication types: Journal Article
Publication Status: epublish
University of Lausanne
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