serval:BIB_1D528EF3931C
SwissSidechain: a molecular and structural database of non-natural sidechains.
10.1093/nar/gks991
000312893300046
23104376
Gfeller
D.
author
Michielin
O.
author
Zoete
V.
author
article
review
2013
Nucleic Acids Research
1362-4962
0305-1048
journal
41
D1
D327-D332
Amino acids form the building blocks of all proteins. Naturally occurring amino acids are restricted to a few tens of sidechains, even when considering post-translational modifications and rare amino acids such as selenocysteine and pyrrolysine. However, the potential chemical diversity of amino acid sidechains is nearly infinite. Exploiting this diversity by using non-natural sidechains to expand the building blocks of proteins and peptides has recently found widespread applications in biochemistry, protein engineering and drug design. Despite these applications, there is currently no unified online bioinformatics resource for non-natural sidechains. With the SwissSidechain database (http://www.swisssidechain.ch), we offer a central and curated platform about non-natural sidechains for researchers in biochemistry, medicinal chemistry, protein engineering and molecular modeling. SwissSidechain provides biophysical, structural and molecular data for hundreds of commercially available non-natural amino acid sidechains, both in l- and d-configurations. The database can be easily browsed by sidechain names, families or physico-chemical properties. We also provide plugins to seamlessly insert non-natural sidechains into peptides and proteins using molecular visualization software, as well as topologies and parameters compatible with molecular mechanics software.
eng
60_published
true
peer-reviewed
Publication types: Journal Article
Article type changed to Review - Bibliomics - Alexandre Pinault
University of Lausanne
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