serval:BIB_127F516B750F
Signature of survival: a <sup>18</sup>F-FDG PET based whole-liver radiomic analysis predicts survival after <sup>90</sup>Y-TARE for hepatocellular carcinoma.
10.18632/oncotarget.23423
000422651700023
29435123
Blanc-Durand
P.
author
Van Der Gucht
A.
author
Jreige
M.
author
Nicod-Lalonde
M.
author
Silva-Monteiro
M.
author
Prior
J.O.
author
Denys
A.
author
Depeursinge
A.
author
Schaefer
N.
author
article
2018-01-12
Oncotarget
1949-2553
1949-2553
journal
9
4
4549-4558
To generate a predictive whole-liver radiomics scoring system for progression-free survival (PFS) and overall survival (OS) in patients undergoing transarterial radioembolization using Yttrium-90 ( <sup>90</sup> Y-TARE) for unresectable hepatocellular carcinoma (uHCC).
The generated pPET-RadScores were significantly correlated with survival for PFS (median of 11.4 mo [95% confidence interval CI: 6.3-16.5 mo] in low-risk group [PFS-pPET-RadScore < 0.09] vs. 4.0 mo [95% CI: 2.3-5.7 mo] in high-risk group [PFS-pPET-RadScore > 0.09]; <i>P</i> = 0.0004) and OS (median of 20.3 mo [95% CI: 5.7-35 mo] in low-risk group [OS-pPET-RadScore < 0.11] vs. 7.7 mo [95% CI: 6.0-9.5 mo] in high-risk group [OS-pPET-RadScore > 0.11]; <i>P</i> = 0.007). The multivariate analysis confirmed PFS-pPET-RadScore ( <i>P</i> = 0.006) and OS-pPET-RadScore ( <i>P</i> = 0.001) as independent negative predictors.
Pretreatment <sup>18</sup> F-FDG PET whole-liver radiomics signature appears as an independent negative predictor for PFS and OS in patients undergoing <sup>90</sup> Y-TARE for uHCC.
Pretreatment <sup>18</sup> F-FDG PET of 47 consecutive patients undergoing <sup>90</sup> Y-TARE for uHCC (31 resin spheres, 16 glass spheres) were retrospectively analyzed. For each patient, based on PET radiomics signature from whole-liver semi-automatic segmentation, PFS and OS predictive PET-radiomics scores (pPET-RadScores) were obtained using LASSO Cox regression. Using X-tile software, the optimal score to predict PFS (PFS-pPET-RadScore) and OS (OS-pPET-RadScore) served as cutoff to separate high and low-risk patients. Survival curves were estimated using the Kaplan-Meier method. The prognostic value of PFS and OS-pPET-RadScore, Barcelona-Clinic Liver Cancer staging system and serum alpha-fetoprotein level was analyzed to predict PFS and OS in multivariate analysis.
18F-FDG PET
TARE
hepatocellular carcinoma
radiomics
survival
eng
60_published
true
peer-reviewed
Publication types: Journal Article
Publication Status: epublish
University of Lausanne
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