serval:BIB_0FBD29996D50
Renal perfusion evaluation with contrast-enhanced ultrasonography.
10.1093/ndt/gfr345
000300421300033
21690200
Schneider
A.G.
author
Hofmann
L.
author
Wuerzner
G.
author
Glatz
N.
author
Maillard
M.
author
Meuwly
J.Y.
author
Eggimann
P.
author
Burnier
M.
author
Vogt
B.
author
article
2012
Nephrology, Dialysis, Transplantation
1460-2385
0931-0509
journal
27
2
674-681
BACKGROUND: Contrast-enhanced ultrasonography (CEUS) is a novel imaging technique that is safe and applicable on the bedside. Recent developments seem to enable CEUS to quantify organ perfusion. We performed an exploratory study to determine the ability of CEUS to detect changes in renal perfusion and to correlate them with effective renal plasma flow.
METHODS: CEUS with destruction-refilling sequences was studied in 10 healthy subjects, at baseline and during infusion of angiotensin II (AngII) at low (1 ng/kg/min) and high dose (3 ng/kg/min) and 1 h after oral captopril (50 mg). Perfusion index (PI) was obtained and compared with the effective renal plasma flow (ERPF) obtained by parallel para-aminohippurate (PAH) clearance.
RESULTS: Median PI decreased from 188.6 (baseline) to 100.4 with low-dose AngII (-47%; P < 0.02) and to 66.1 with high-dose AngII (-65%; P < 0.01) but increased to 254.7 with captopril (+35%; P > 0.2). These changes parallelled those observed with ERPF, which changed from a median of 672.1 mL/min (baseline) to 572.3 (low-dose AngII, -15%, P < 0.05) and to 427.2 (high-dose AngII, -36%, P < 0.001) and finally 697.1 (captopril, +4%, P < 0.02).
CONCLUSIONS: This study demonstrates that CEUS is able to detect changes in human renal cortical microcirculation as induced by AngII infusion and/or captopril administration. The changes in perfusion indices parallel those in ERPF as obtained by PAH clearance.
Adult
Angiotensin II/pharmacology
Captopril/pharmacology
Cohort Studies
Contrast Media/diagnostic use
Humans
Image Enhancement/methods
Kidney Cortex/blood supply
Kidney Cortex/drug effects
Male
Microcirculation/drug effects
Microcirculation/physiology
Observer Variation
Reference Values
Renal Circulation/drug effects
Renal Circulation/physiology
Renal Plasma Flow, Effective/drug effects
Sensitivity and Specificity
Ultrasonography, Doppler/methods
Young Adult
eng
60_published
true
peer-reviewed
Publication types: Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
University of Lausanne
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