serval:BIB_0796969CC0A5
Enteric Microbiota⁻Gut⁻Brain Axis from the Perspective of Nuclear Receptors.
10.3390/ijms19082210
000442869800062
30060580
Duszka
K.
author
Wahli
W.
author
article
review
2018-07-28
International journal of molecular sciences
1422-0067
1422-0067
journal
19
8
E2210
Nuclear receptors (NRs) play a key role in regulating virtually all body functions, thus maintaining a healthy operating body with all its complex systems. Recently, gut microbiota emerged as major factor contributing to the health of the whole organism. Enteric bacteria have multiple ways to influence their host and several of them involve communication with the brain. Mounting evidence of cooperation between gut flora and NRs is already available. However, the full potential of the microbiota interconnection with NRs remains to be uncovered. Herewith, we present the current state of knowledge on the multifaceted roles of NRs in the enteric microbiota⁻gut⁻brain axis.
Animals
Bacteria/metabolism
Bacterial Physiological Phenomena
Brain/physiology
Gastrointestinal Microbiome
Gastrointestinal Tract/microbiology
Gastrointestinal Tract/physiology
Humans
Receptors, Cytoplasmic and Nuclear/metabolism
Signal Transduction
metabolism
microbiota
nuclear receptors
xenobiotics
eng
60_published
true
peer-reviewed
Publication types: Journal Article ; Review
Publication Status: epublish
University of Lausanne
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