serval:BIB_05680BF51A16
Mechanisms of inflammation in gout.
10.1186/ar2952
000280227200008
20441605
Busso
N.
author
So
A.
author
article
review
2010
Arthritis Research and Therapy
1478-6362[electronic], 1478-6354[linking]
journal
12
2
206
An acute attack of gout is a paradigm of acute sterile inflammation, as opposed to pyogenic inflammation. Recent studies suggest that the triggering of IL-1beta release from leucocytes lies at the heart of a cascade of processes that involves multiple cytokines and mediators. The NLRP3 inflammasome appears to have a specific role in this regard, but the biochemical events leading to its activation are still not well understood. We review the known mechanisms that underlie the inflammatory process triggered by urate crystals and suggest areas that require further research.
Acute Disease
Animals
Carrier Proteins/immunology
Chemotaxis, Leukocyte/immunology
Crystallization
Disease Models, Animal
Gout/immunology
Gout/pathology
Humans
Inflammation/immunology
Inflammation/pathology
Interleukin-1beta/secretion
Leukocytes/immunology
Leukocytes/pathology
Phagocytosis
Uric Acid/immunology
eng
60_published
true
University of Lausanne
mailto:serval_help@unil.ch
http://www.unil.ch/serval
http://serval.unil.ch/disclaimer
https://serval.unil.ch/notice/serval:BIB_05680BF51A16