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Mary-Anne Hartley, Alyssa Young, Anh-Minh Tran, Harry Henry Okoni-Williams, Mohamed Suma, Brooke Mancuso, Ahmed Al-Dikhari, Mohamed Faouzi
Predicting Ebola Severity: A Clinical Prioritization Score for Ebola Virus Disease
www.plosntds.org
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1.8935 0 Td
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1.0261 0 Td
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3.4413 0 Td
(the)Tj
1.4683 0 Td
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5.709 0 Td
(co-infection)Tj
5.074 0 Td
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-34.5654 -1.2983 Td
(malaria)Tj
3.2258 0 Td
(parasite,)Tj
/F11 1 Tf
3.5489 0 Td
[()4()4()10(\r)6()4()12()12(\n)12(\r)]TJ
5.1364 0 Td
[()9()11()4()1()10()4()16()-9(\n)12(\r)]TJ
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1.5364 0 Td
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2.2167 0 Td
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(24)Tj
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-33.3295 -1.2983 Td
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1.3266 0 Td
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3.1181 0 Td
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1.474 0 Td
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3.0728 0 Td
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1.7347 0 Td
(epidemiological)Tj
6.5594 0 Td
(data)Tj
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-34.0155 -1.2982 Td
(158)Tj
1.644 0 Td
(EVD\(+\))Tj
3.481 0 Td
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1.474 0 Td
(GOAL-Mathaska)Tj
7.132 0 Td
(ETC)Tj
2.0636 0 Td
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1.0318 0 Td
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1.9559 0 Td
(Loko,)Tj
2.4944 0 Td
(Sierra)Tj
2.5626 0 Td
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2.8856 0 Td
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-34.9339 -1.2983 Td
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4.4617 0 Td
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1.4683 0 Td
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1.0148 0 Td
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3.2258 0 Td
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1.0375 0 Td
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2.2167 0 Td
(pathogenesis)Tj
5.3574 0 Td
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1.7291 0 Td
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3.4583 0 Td
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1.474 0 Td
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-33.4542 -1.3039 Td
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4.3313 0 Td
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1.2755 0 Td
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-34.6845 -1.2983 Td
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1.3266 0 Td
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3.9798 0 Td
(a)Tj
0.6576 0 Td
(statistically)Tj
4.6092 0 Td
(weighted)Tj
3.838 0 Td
(disease)Tj
3.0161 0 Td
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3.1634 0 Td
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3.1634 0 Td
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1.4684 0 Td
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(that)Tj
1.7745 0 Td
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1.0148 0 Td
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Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 470.2677 cm
BT
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1 TL
-0.0033 Tc
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0 -1.5023 Td
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ET
Q
q
1 j
1 J
0 w
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BT
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1 TL
-0.004 Tc
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3.532 0 Td
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4.3483 0 Td
(14,)Tj
-36.1868 -1.3039 Td
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2.1203 0 Td
(and)Tj
1.7291 0 Td
(November)Tj
4.4673 0 Td
(15,)Tj
1.3947 0 Td
(2015)Tj
2.1203 0 Td
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0.9524 0 Td
(the)Tj
1.474 0 Td
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2.9027 0 Td
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1.0375 0 Td
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1.9559 0 Td
(Loko,)Tj
2.4888 0 Td
(Sierra)Tj
2.5625 0 Td
(Leone.)Tj
2.8913 0 Td
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2.1203 0 Td
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-32.2807 -1.2982 Td
(patient)Tj
2.999 0 Td
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6.0831 0 Td
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4.6091 0 Td
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3.668 0 Td
(clinical)Tj
3.0727 0 Td
(signs)Tj
2.2111 0 Td
(and)Tj
1.7234 0 Td
(symptoms,)Tj
4.5751 0 Td
(and)Tj
1.7235 0 Td
(laboratory)Tj
4.3426 0 Td
(results)Tj
-35.0076 -1.2983 Td
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1.7234 0 Td
(malaria)Tj
3.2258 0 Td
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3.7927 0 Td
(and)Tj
1.7292 0 Td
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7.1999 0 Td
(Ebola)Tj
2.4832 0 Td
(viremia\),)Tj
3.8267 0 Td
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1.0148 0 Td
(well)Tj
1.8198 0 Td
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1.0148 0 Td
(the)Tj
1.4684 0 Td
(final)Tj
2.0012 0 Td
(patient)Tj
3.0104 0 Td
(out-)Tj
-34.3103 -1.3039 Td
(come)Tj
2.3924 0 Td
(of)Tj
1.0148 0 Td
(death)Tj
2.4321 0 Td
(or)Tj
1.0998 0 Td
(survival.)Tj
3.5603 0 Td
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1.6101 0 Td
(evaluate)Tj
3.4582 0 Td
(the)Tj
1.474 0 Td
(potential)Tj
3.7587 0 Td
(of)Tj
1.0148 0 Td
(clinical)Tj
3.0785 0 Td
(characteristics)Tj
5.9016 0 Td
(in)Tj
1.0375 0 Td
(predicting)Tj
-31.8328 -1.2983 Td
(EVD)Tj
2.2166 0 Td
(mortality)Tj
3.9175 0 Td
(and)Tj
1.7291 0 Td
(use)Tj
1.5364 0 Td
(these)Tj
2.2507 0 Td
(results)Tj
2.8119 0 Td
(to)Tj
1.0262 0 Td
(construct)Tj
3.9798 0 Td
(a)Tj
0.6519 0 Td
(symptom-based)Tj
6.5991 0 Td
(disease)Tj
3.0217 0 Td
(staging)Tj
3.0557 0 Td
(system,)Tj
-32.7966 -1.2982 Td
(which)Tj
2.6475 0 Td
(corresponds)Tj
5.142 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(prognostic)Tj
4.4844 0 Td
(power)Tj
2.7212 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(most)Tj
2.2053 0 Td
(prevalent)Tj
3.9345 0 Td
(symptoms.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 328.1385 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Patient)Tj
3.2976 0 Td
(referral)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 311.1307 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
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1.7801 0 Td
(ETC)Tj
2.0636 0 Td
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1.7008 0 Td
(run)Tj
1.6667 0 Td
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1.1849 0 Td
(the)Tj
1.4684 0 Td
(humanitarian)Tj
5.6976 0 Td
(organization)Tj
5.278 0 Td
(GOAL)Tj
2.9084 0 Td
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2.8743 0 Td
(in)Tj
1.0374 0 Td
(cooperation)Tj
5.023 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
-34.6788 -1.2982 Td
(Sierra)Tj
2.5625 0 Td
(Leonean)Tj
3.6396 0 Td
(Ministry)Tj
3.685 0 Td
(of)Tj
1.0148 0 Td
(Health)Tj
2.914 0 Td
(and)Tj
1.7348 0 Td
(Sanitation)Tj
4.2973 0 Td
(\(MoHS\).)Tj
3.7644 0 Td
(The)Tj
1.7858 0 Td
(ETC)Tj
2.0636 0 Td
(opened)Tj
3.1691 0 Td
(in)Tj
1.0318 0 Td
(December)Tj
-31.6627 -1.3039 Td
(2014)Tj
2.1203 0 Td
(and)Tj
1.7291 0 Td
(accepted)Tj
3.6907 0 Td
(600)Tj
1.6497 0 Td
(patients)Tj
3.3676 0 Td
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2.2053 0 Td
(a)Tj
0.6576 0 Td
(catchment)Tj
4.4164 0 Td
(area)Tj
1.8822 0 Td
(spanning)Tj
3.9061 0 Td
(200km.)Tj
3.1918 0 Td
(EVD)Tj
2.2223 0 Td
(surveillance)Tj
4.9436 0 Td
(in)Tj
-35.9827 -1.2983 Td
(Sierra)Tj
2.5625 0 Td
(Leone)Tj
2.6588 0 Td
(was)Tj
1.7008 0 Td
(implemented)Tj
5.5332 0 Td
(through)Tj
3.4469 0 Td
(District)Tj
3.2428 0 Td
(Ebola)Tj
2.4832 0 Td
(Response)Tj
3.9854 0 Td
(Centres)Tj
3.3052 0 Td
(\(DERCs\).)Tj
4.0762 0 Td
(Individuals)Tj
-32.995 -1.2983 Td
(who)Tj
1.9388 0 Td
(were)Tj
2.1203 0 Td
(sick)Tj
1.7688 0 Td
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2.1203 0 Td
(encouraged)Tj
4.8756 0 Td
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1.0261 0 Td
(report)Tj
2.7043 0 Td
(their)Tj
2.1089 0 Td
(illness)Tj
2.6759 0 Td
(\(or)Tj
1.44 0 Td
(the)Tj
1.4684 0 Td
(suspected)Tj
4.0818 0 Td
(illness)Tj
2.6759 0 Td
(of)Tj
1.0148 0 Td
(others\))Tj
3.0444 0 Td
(via)Tj
-35.0643 -1.2982 Td
(the)Tj
1.4683 0 Td
(national)Tj
3.5036 0 Td
(or)Tj
1.0998 0 Td
(district)Tj
3.0331 0 Td
(Ebola)Tj
2.4831 0 Td
(call-lines.)Tj
3.9912 0 Td
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4.7225 0 Td
(that)Tj
1.7801 0 Td
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1.7631 0 Td
(the)Tj
1.4684 0 Td
(WHO)Tj
2.6985 0 Td
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1.8596 0 Td
(definition)Tj
4.1669 0 Td
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1.3833 0 Td
(EVD)Tj
-35.4215 -1.3039 Td
([)Tj
0.83 0.64 0.02 0 k
(25)Tj
0 g
(],)Tj
2.0749 0 Td
(as)Tj
1.0148 0 Td
(well)Tj
1.8198 0 Td
(as)Tj
1.0148 0 Td
(those)Tj
2.3358 0 Td
(with)Tj
2.0012 0 Td
(confirmed)Tj
4.3937 0 Td
(EVD)Tj
2.2223 0 Td
(infection,)Tj
4.0139 0 Td
(were)Tj
2.1259 0 Td
(referred)Tj
3.4186 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
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2.0636 0 Td
(from)Tj
2.2053 0 Td
(surround-)Tj
-33.1991 -1.2983 Td
(ing)Tj
1.491 0 Td
(communities,)Tj
5.6976 0 Td
(holding)Tj
3.2995 0 Td
(centres,)Tj
3.2881 0 Td
(health)Tj
2.6646 0 Td
(facilities,)Tj
3.7134 0 Td
(and)Tj
1.7177 0 Td
(quarantine)Tj
4.5751 0 Td
(houses.)Tj
3.1408 0 Td
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1.389 0 Td
(EVD\(+\))Tj
3.4695 0 Td
(patients)Tj
-34.4463 -1.2983 Td
(were)Tj
2.1203 0 Td
(treated)Tj
2.999 0 Td
(according)Tj
4.1839 0 Td
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1.0261 0 Td
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3.7247 0 Td
(treatment)Tj
4.1329 0 Td
(protocols)Tj
3.9628 0 Td
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4.269 0 Td
(by)Tj
1.1792 0 Td
(WHO)Tj
2.7042 0 Td
(and)Tj
1.7291 0 Td
(Me)Tj
0 Tc
0.9128 0.0511 Td
()Tj
-0.004 Tc
0.4025 -0.0511 Td
(decins)Tj
-33.3465 -1.3039 Td
(Sans)Tj
2.0352 0 Td
(Fronti)Tj
/F12 1 Tf
[()]TJ
/F7 1 Tf
(res)Tj
4.3143 0 Td
([)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(26)Tj
0 g
(].)Tj
1.7348 0 Td
(This)Tj
1.9899 0 Td
(included)Tj
3.7077 0 Td
(empiric)Tj
3.3108 0 Td
(antimalarial)Tj
5.023 0 Td
(treatment)Tj
4.1329 0 Td
(\(Artesunate)Tj
4.9322 0 Td
(and)Tj
1.7292 0 Td
(Amo-)Tj
-34.6448 -1.2983 Td
(diaquine\),)Tj
4.2859 0 Td
(broad-spectrum)Tj
6.6614 0 Td
(antibiotics,)Tj
4.6204 0 Td
(and)Tj
1.7348 0 Td
(nutritional)Tj
4.5354 0 Td
(supplementation)Tj
6.9562 0 Td
(for)Tj
1.3833 0 Td
(all)Tj
1.1509 0 Td
(patients,)Tj
3.5886 0 Td
(as)Tj
1.0148 0 Td
(well)Tj
-35.9317 -1.2982 Td
(as)Tj
1.0147 0 Td
(oral)Tj
1.7745 0 Td
(or)Tj
1.0999 0 Td
(intravenous)Tj
4.9606 0 Td
(fluid)Tj
2.0806 0 Td
(rehydration.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 139.011 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Data)Tj
2.3102 0 Td
(collection)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 122.0031 cm
BT
/F7 1 Tf
1 TL
-0.004 Tc
0 0 Td
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2.3357 0 Td
(and)Tj
1.7291 0 Td
(symptoms)Tj
4.3597 0 Td
(were)Tj
2.1203 0 Td
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3.7984 0 Td
(daily,)Tj
2.3754 0 Td
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1.2756 0 Td
(admission)Tj
4.3143 0 Td
(and)Tj
1.7291 0 Td
(throughout)Tj
4.7792 0 Td
(the)Tj
1.4683 0 Td
(patients')Tj
3.583 0 Td
(length)Tj
2.7269 0 Td
(of)Tj
-36.595 -1.2982 Td
(stay)Tj
1.7688 0 Td
(at)Tj
0.9524 0 Td
(the)Tj
1.4683 0 Td
(ETC.)Tj
2.2904 0 Td
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2.3584 0 Td
(triaged,)Tj
3.2372 0 Td
(blood)Tj
2.5114 0 Td
(was)Tj
1.7008 0 Td
(drawn)Tj
2.7836 0 Td
(and)Tj
1.7291 0 Td
(tested)Tj
2.5569 0 Td
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1.3833 0 Td
(EVD)Tj
2.2223 0 Td
(in)Tj
1.0318 0 Td
(on-site)Tj
2.9764 0 Td
(laboratories)Tj
-30.9711 -1.3039 Td
(managed)Tj
3.8721 0 Td
(by)Tj
1.1792 0 Td
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2.7495 0 Td
(Heath)Tj
2.6759 0 Td
(England.)Tj
3.7814 0 Td
(EVD)Tj
2.2224 0 Td
(diagnosis)Tj
3.9571 0 Td
(was)Tj
1.7008 0 Td
(determined)Tj
4.8472 0 Td
(by)Tj
1.1849 0 Td
(semi-quantitative)Tj
-28.1705 -1.2983 Td
(reverse)Tj
3.05 0 Td
(transcriptase-PCR)Tj
7.5231 0 Td
(\(qRT-PCR\))Tj
4.8302 0 Td
(as)Tj
1.0148 0 Td
(previously)Tj
4.354 0 Td
(described)Tj
4.0535 0 Td
([)Tj
0.83 0.64 0.02 0 k
(27)Tj
0 g
(].)Tj
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