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Protective role of NFATc2 in CD8+ long lived memory T cells in an allergy model : P234
000259367100425
Karwot
R.
author
Maxeiner
J.
author
Schmitt
S.
author
Scholtes
P.
author
Hausding
M.
author
Lehr
H. A.
author
Glimcher
L.H.
author
Finotto
S.
author
inproceedings
poster
2008
Vienna, September 3-6, 2008
Abstracts of the Joint Annual Meeting of Immunology of the Austrian and German Societies (ÖGAI, DGfI)
0043-5325
Wiener Klinische Wochenschrift
conference publication
120
130-131
eng
60_published
peer-reviewed
The development of allergic immune responses is mediated by CD4+ effector T cells producing T helper 2 (Th2) cytokines as well as by CD8+ T cells that predominate over cytokines such as interferon-gamma (IFN-γ). However the role of IFN-γ in asthma is not fully understood. We demonstrate that mice
lacking nuclear factor of activated T cells-2 (NFATc2) developed increased airway hyperresponsiveness (AHR) and had increased serum IgE levels in the absence of exogenous allergen challenge. This AHR is associated with increased Th2 CD4+ T cell as well as CD8+ T cells defective in interferongamma (IFN-γ) and IL-2 production. Moreover, lung CD8+ T
cells from NFATc2 (-/-) mice contained increased numbers of CD8+ CD122+ CD127+ long lived memory T cells releasing increased amounts of interleukin-10 (IL-10). Adoptive transfer of ovalbumin (OVA) specific NFATc2 (-/-) CD8+ and NFATc2 (-/-) CD4+ T cells enhanced AHR and IL-17 levels while reducing IFN-γ in the airways of SCID reconstituted mice as compared
to those adoptively transferred with NFATc2(+/+)CD8+ and NFATc2 (-/-) CD4+ T cells . Interestingly, depletion of CD8+CD122+ T cells abrogated the increased AHR, eosinophils, and increased IFN-gamma observed in the BALF
of CD4+ NFATc2 (-/-) /CD8+ NFATc2 (-/-) T cell-reconstituted SCID mice. In conclusion NFATc2 expression in long lived memory CD8+ T cells controls directly the IFN-γ and IL-2 expression in CD8+ T cell, which then limits Th17 and Th2 development in the airways in this allergy model.