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Aspergillus fumigatus conidial metalloprotease Mep1p cleaves host complement proteins.
10.1074/jbc.RA117.001476
000446549200019
30139746
Shende
R.
author
Wong
SSW
author
Rapole
S.
author
Beau
R.
author
Ibrahim-Granet
O.
author
Monod
M.
author
Gührs
K.H.
author
Pal
J.K.
author
Latgé
J.P.
author
Madan
T.
author
Aimanianda
V.
author
Sahu
A.
author
article
2018-10-05
The Journal of biological chemistry
1083-351X
0021-9258
journal
293
40
15538-15555
Animals
Aspergillus fumigatus/growth & development
Aspergillus fumigatus/immunology
Aspergillus fumigatus/pathogenicity
Collagen/genetics
Collagen/immunology
Complement C3/genetics
Complement C3/metabolism
Complement C4/genetics
Complement C4/metabolism
Complement C5/genetics
Complement C5/metabolism
Disease Models, Animal
Fungal Proteins/genetics
Fungal Proteins/immunology
Gene Expression Regulation
Host-Pathogen Interactions
Humans
Immune Evasion
Immunity, Innate
Invasive Pulmonary Aspergillosis/genetics
Invasive Pulmonary Aspergillosis/immunology
Invasive Pulmonary Aspergillosis/microbiology
Invasive Pulmonary Aspergillosis/pathology
Lectins/genetics
Lectins/immunology
Lung/immunology
Lung/pathology
Macrophages/immunology
Macrophages/microbiology
Male
Mannose-Binding Protein-Associated Serine Proteases/genetics
Mannose-Binding Protein-Associated Serine Proteases/immunology
Metalloendopeptidases/deficiency
Metalloendopeptidases/genetics
Metalloendopeptidases/immunology
Mice
Mice, Inbred BALB C
Mice, Knockout
Phagocytosis
Spores, Fungal/growth & development
Spores, Fungal/immunology
Spores, Fungal/pathogenicity
Aspergillus
Aspergillus fumigatus
complement
complement system
immune evasion
infectious disease
inflammation
metalloprotease
phagocytosis
eng
60_published
peer-reviewed
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish