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Mice Hypomorphic for Keap1, a Negative Regulator of the Nrf2 Antioxidant Response, Show Age-Dependent Diffuse Goiter with Elevated Thyrotropin Levels.
10.1089/thy.2020.0044
000563582800001
32689903
Ziros
P.G.
author
Renaud
C.O.
author
Chartoumpekis
D.V.
author
Bongiovanni
M.
author
Habeos
I.G.
author
Liao
X.H.
author
Refetoff
S.
author
Kopp
P.A.
author
Brix
K.
author
Sykiotis
G.P.
author
article
2021-01
Thyroid
1557-9077
1050-7256
journal
31
1
23-35
Age Factors
Animals
Biomarkers/blood
Genetic Predisposition to Disease
Goiter, Nodular/blood
Goiter, Nodular/genetics
Goiter, Nodular/pathology
Kelch-Like ECH-Associated Protein 1/deficiency
Kelch-Like ECH-Associated Protein 1/genetics
Male
Mice, Inbred C57BL
Mice, Knockout
NF-E2-Related Factor 2/genetics
NF-E2-Related Factor 2/metabolism
Oxidative Stress
Phenotype
Thyroglobulin/metabolism
Thyroid Gland/metabolism
Thyroid Gland/pathology
Thyrotropin/blood
Up-Regulation
Keap1 hypomorphism
Nfe2l2
cathepsin
oxidative stress
thyroglobulin
thyroid
eng
60_published
true
peer-reviewed
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
https://serval.unil.ch/notice/serval:BIB_62561B304595
https://serval.unil.ch/resource/serval:BIB_62561B304595.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_62561B3045953
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