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Trametinib Induces the Stabilization of a Dual GNAQ p.Gly48Leu- and FGFR4 p.Cys172Gly-Mutated Uveal Melanoma. The Role of Molecular Modelling in Personalized Oncology.
10.3390/ijms21218021
000588991800001
33126538
Krebs
F.S.
author
Gérard
C.
author
Wicky
A.
author
Aedo-Lopez
V.
author
Missiaglia
E.
author
Bisig
B.
author
Trimech
M.
author
Michielin
O.
author
Homicsko
K.
author
Zoete
V.
author
article
2020-10-28
International journal of molecular sciences
1422-0067
1422-0067
journal
21
21
E8021
Amino Acid Sequence
Antineoplastic Agents/therapeutic use
Female
GTP-Binding Protein alpha Subunits, Gq-G11/chemistry
GTP-Binding Protein alpha Subunits, Gq-G11/genetics
GTP-Binding Protein alpha Subunits, Gq-G11/metabolism
Humans
Melanoma/drug therapy
Melanoma/genetics
Melanoma/metabolism
Melanoma/pathology
Middle Aged
Models, Molecular
Mutant Proteins/chemistry
Mutant Proteins/genetics
Mutant Proteins/metabolism
Mutation
Protein Conformation
Protein Stability
Pyridones/therapeutic use
Pyrimidinones/therapeutic use
Receptor, Fibroblast Growth Factor, Type 4/chemistry
Receptor, Fibroblast Growth Factor, Type 4/genetics
Receptor, Fibroblast Growth Factor, Type 4/metabolism
Sequence Homology
Signal Transduction
Uveal Neoplasms/drug therapy
Uveal Neoplasms/genetics
Uveal Neoplasms/metabolism
Uveal Neoplasms/pathology
FGFR4
GNAQ
molecular modelling
mutation
precision oncology
eng
60_published
true
peer-reviewed
Publication types: Case Reports ; Journal Article
Publication Status: epublish
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https://serval.unil.ch/resource/serval:BIB_44F221AEB60A.P001/REF.pdf
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