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2024-03-23T02:08:22Z
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Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
10.1038/nature03659
15959515
000229799700050
J. H.
van Es
author
M. E.
van Gijn
author
O.
Riccio
author
M.
van den Born
author
M.
Vooijs
author
H.
Begthel
author
M.
Cozijnsen
author
S.
Robine
author
D. J.
Winton
author
F.
Radtke
author
H.
Clevers
author
article
2005-06
Nature
1476-4687
journal
435
7044
959-63
Adenoma/enzymology/genetics/metabolism/*pathology
Amyloid Precursor Protein Secretases
Animals
Aspartic Endopeptidases
Cell Differentiation/drug effects
Cell Proliferation/*drug effects
DNA-Binding Proteins/deficiency/genetics/metabolism
Dibenzazepines/pharmacology
Endopeptidases/*metabolism
Female
Genes, APC
Goblet Cells/*cytology/drug effects/metabolism/pathology
Immunoglobulin J Recombination Signal Sequence-Binding Protein
Intestine, Small/*cytology/drug effects/enzymology/metabolism
Male
Membrane Proteins/*antagonists & inhibitors/metabolism
Mice
Mice, Inbred C57BL
Nuclear Proteins/deficiency/genetics/metabolism
Phenotype
Protease Inhibitors/*pharmacology
Receptors, Notch
Signal Transduction/drug effects
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun 16
60_published