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Design, synthesis, and pharmacological evaluation of conformationally constrained analogues of N,N'-diaryl- and N-aryl-N-aralkylguanidines as potent inhibitors of neuronal Na+ channels
10.1021/jm980124a
9685245
000075111400017
M. C.
Maillard
author
M. E.
Perlman
author
O.
Amitay
author
D.
Baxter
author
D.
Berlove
author
S.
Connaughton
author
J. B.
Fischer
author
J. Q.
Guo
author
L. Y.
Hu
author
R. N.
McBurney
author
P. I.
Nagy
author
K.
Subbarao
author
E. A.
Yost
author
L.
Zhang
author
G. J.
Durant
author
article
1998-07
Journal of Medicinal Chemistry
0022-2623
journal
41
16
3048-61
Animals
Anticonvulsants/chemical synthesis/chemistry/metabolism/pharmacology
Biological Transport
Brain/drug effects/metabolism/ultrastructure
CHO Cells
Calcium/metabolism
Calcium Channel Blockers/chemical
synthesis/chemistry/metabolism/pharmacology
Calcium Channels/drug effects
Cricetinae
*Drug Design
Female
Guanidine/metabolism
*Imidazoles/chemical synthesis/chemistry/metabolism/pharmacology
Male
Mice
Mice, Inbred DBA
Molecular Conformation
Neurons/*drug effects/metabolism
*Pyrimidines/chemical synthesis/chemistry/metabolism/pharmacology
Rats
Receptors, N-Methyl-D-Aspartate/metabolism
Seizures/prevention & control
*Sodium Channel Blockers
Sodium Channels/biosynthesis
Structure-Activity Relationship
Synaptosomes/drug effects/metabolism
Journal Article --- Old month value: Jul 30
60_published