Complement activation products in plasma after heart transplantation in humans

Détails

ID Serval
serval:BIB_FFEC9FDB1B2E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Complement activation products in plasma after heart transplantation in humans
Périodique
Transplantation
Auteur(s)
Vallhonrat  H., Williams  W. W., Dec  G. W., Keck  S., Schoenfeld  D., Cosimi  A. B., Pascual  M.
ISSN
0041-1337
Statut éditorial
Publié
Date de publication
05/2001
Peer-reviewed
Oui
Volume
71
Numéro
9
Pages
1308-11
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May 15
Résumé
BACKGROUND: Complement activation has recently been implicated as a contributing factor to early and late allograft dysfunction in cardiac transplantation. The current study was designed to determine whether measurement of plasma complement fragments C4d and SC5b-9 would be useful in detecting acute rejection or accelerated graft atherosclerosis (AGA) in cardiac allograft recipients. METHODS: We measured complement activation products, C4d (classical pathway) and SC5b-9 (terminal pathway), at the time of routine endomyocardial biopsy in heart transplant recipients. Ten patients in the immediate posttransplantation period (0-100 days) and 19 patients more than 6 months after transplantation were studied. RESULTS: No correlation was found between plasma levels of complement activation fragments and the presence of biopsy-proven acute allograft rejection or AGA (assessed by coronary angiography). However, plasma C4d and SC5b-9 were significantly elevated in 9 of 10 and 7 of 10 patients, respectively, in the immediate posttransplantation period. This was followed by progressive decrease in the levels of C4d and SC5b-9 fragments during the first 4-6 weeks after transplantation. CONCLUSION: We conclude that measuring plasma levels of fragments C4d and SC5b-9 is not a useful noninvasive method for detecting acute rejection or AGA after heart transplantation. However, this study provides further evidence that early complement activation after heart transplantation may play a pathogenic role in allograft injury.
Mots-clé
Complement Activation/*physiology Complement C4/analysis *Complement C4b Complement C5/analysis Complement C5b Complement System Proteins/*metabolism *Heart Transplantation Humans Peptide Fragments/analysis/*blood Time Factors
Pubmed
Web of science
Création de la notice
29/01/2008 14:52
Dernière modification de la notice
03/03/2018 23:09
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