Complement activation products in plasma after heart transplantation in humans
Details
Serval ID
serval:BIB_FFEC9FDB1B2E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Complement activation products in plasma after heart transplantation in humans
Journal
Transplantation
ISSN
0041-1337
Publication state
Published
Issued date
05/2001
Peer-reviewed
Oui
Volume
71
Number
9
Pages
1308-11
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May 15
Research Support, Non-U.S. Gov't --- Old month value: May 15
Abstract
BACKGROUND: Complement activation has recently been implicated as a contributing factor to early and late allograft dysfunction in cardiac transplantation. The current study was designed to determine whether measurement of plasma complement fragments C4d and SC5b-9 would be useful in detecting acute rejection or accelerated graft atherosclerosis (AGA) in cardiac allograft recipients. METHODS: We measured complement activation products, C4d (classical pathway) and SC5b-9 (terminal pathway), at the time of routine endomyocardial biopsy in heart transplant recipients. Ten patients in the immediate posttransplantation period (0-100 days) and 19 patients more than 6 months after transplantation were studied. RESULTS: No correlation was found between plasma levels of complement activation fragments and the presence of biopsy-proven acute allograft rejection or AGA (assessed by coronary angiography). However, plasma C4d and SC5b-9 were significantly elevated in 9 of 10 and 7 of 10 patients, respectively, in the immediate posttransplantation period. This was followed by progressive decrease in the levels of C4d and SC5b-9 fragments during the first 4-6 weeks after transplantation. CONCLUSION: We conclude that measuring plasma levels of fragments C4d and SC5b-9 is not a useful noninvasive method for detecting acute rejection or AGA after heart transplantation. However, this study provides further evidence that early complement activation after heart transplantation may play a pathogenic role in allograft injury.
Keywords
Complement Activation/*physiology
Complement C4/analysis
*Complement C4b
Complement C5/analysis
Complement C5b
Complement System Proteins/*metabolism
*Heart Transplantation
Humans
Peptide Fragments/analysis/*blood
Time Factors
Pubmed
Web of science
Create date
29/01/2008 14:52
Last modification date
20/08/2019 17:30