Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Prévention de l'ostéoporose postménopausique par traitement hormonal substitutif: les risques sont-ils encore acceptables? [Preventing of postmenopausal osteoporosis by hormone replacement therapy? Is the risk acceptable?]
Schweizerische Rundschau fur Medizin Praxis
English Abstract Journal Article Review --- Old month value: Feb 25
Over the past two decades, multiple observational studies have suggested that hormone replacement therapy (HRT) reduced the risk of fracture, increased the quality of life and protected against the cardiovascular disease. HRT was often recommended, on the basis of this evidence, for that indications. But these recommendations were based entirely on observational evidence, which can sometimes be misleading. In the early 1990, several large randomized studies were initiated. The largest of these trials, the Women Health Initiative (WHI) was stopped prematurely last summer (only the group with estrogen plus progestin) because the disadvantages outweighted the advantages of treatment. The conclusions of that study were largely debated in the press and destabilised more than one patient or doctor. The Swiss menopausal society published some directive to precise the indications of HRT.
Age Factors Aged Alzheimer Disease/epidemiology Breast Neoplasms/epidemiology Cardiovascular Diseases/epidemiology/prevention & control Climacteric Colonic Neoplasms/epidemiology Endometrial Neoplasms/epidemiology Estrogens, Conjugated (USP)/administration & dosage Female Follow-Up Studies *Hormone Replacement Therapy/adverse effects Humans Hysterectomy Medroxyprogesterone/administration & dosage Meta-Analysis Middle Aged Multivariate Analysis Osteoporosis, Postmenopausal/*prevention & control Ovarian Neoplasms/epidemiology Placebos Prognosis Prospective Studies Quality of Life Randomized Controlled Trials Risk Risk Factors Socioeconomic Factors Time Factors
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