Characterization of an HLA-DR beta pseudogene in the DRw52 supertypic group.

Details

Serval ID
serval:BIB_FEB0B0D0F9C7
Type
Article: article from journal or magazin.
Collection
Publications
Title
Characterization of an HLA-DR beta pseudogene in the DRw52 supertypic group.
Journal
Immunogenetics
Author(s)
Rollini P., Mach B., Gorski J.
ISSN
0093-7711 (Print)
ISSN-L
0093-7711
Publication state
Published
Issued date
1987
Volume
25
Number
5
Pages
336-342
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
The nature of the DR beta II pseudogene in a haplotype of the DRw52 supertypic group was investigated by nucleotide sequence analysis. It revealed several deleterious mutations in the signal sequence and second domain regions in addition to the complete absence of the first domain and adjacent sequences. No expression of DR beta II pseudogene mRNA can be detected. The same DR beta II pseudogene is probably present in other members of the DRw52 supertypic group. The pattern of mutations in this DR beta II pseudogene is different from that observed in the DR beta pseudogene of the DRw53 supertypic group, indicating a distinct evolutionary pathway for these two groups of DR haplotypes.
Keywords
Amino Acid Sequence, Base Sequence, Cell Line, Cosmids, DNA Restriction Enzymes, Genes, HLA-D Antigens/genetics, HLA-DR Antigens/genetics, HLA-DR2 Antigen, Haplotypes, Humans, Nucleic Acid Hybridization
Pubmed
Web of science
Create date
11/11/2011 11:14
Last modification date
20/08/2019 16:29
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