Comparaison de stratégies thérapeutiques dans la prise en charge de l'hypertension artérielle [Comparison of therapeutic strategies in the management of hypertension]

Details

Serval ID
serval:BIB_FD8AABE6480F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Comparaison de stratégies thérapeutiques dans la prise en charge de l'hypertension artérielle [Comparison of therapeutic strategies in the management of hypertension]
Journal
Current Medical Research and Opinion
Author(s)
Waeber B.
ISSN
0300-7995
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
21
Number
Suppl 5
Pages
S13-S16
Language
french
Abstract
Guidelines for the treatment of hypertension recommend reducing blood pressure to below 140/90 mmHg. However, there is little to guide the clinician on which pharmacological strategy to pursue: monotherapy with stepped-care, sequential monotherapy, or the initial use of combination therapy. The STRATHE study was designed to clarify this issue by comparing the three strategies. A low-dose combination of perindopril/indapamide was significantly superior to either stepped-care or sequential monotherapy in terms of reducing systolic blood pressure and in the percentage of patients achieving normalisation without adverse effects. Pulse pressure showed a trend to greater reductions with the low-dose combination. Although there must be caution about extrapolating these results to other combinations, which may not have the same pharmacological properties, the STRATHE study has shown that initiating antihypertensive therapy with a low-dose combination has advantages over the two other classical therapeutic strategies.
Keywords
Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Diuretics, Drug Therapy, Combination, France, Humans, Hypertension, Indapamide, Perindopril
Pubmed
Create date
06/03/2009 12:00
Last modification date
20/08/2019 16:28
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