Predictors of favourable outcome in first-episode patients who refuse medication: results from the FEPOS study

Détails

ID Serval
serval:BIB_FCB8B5FE9367
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Titre
Predictors of favourable outcome in first-episode patients who refuse medication: results from the FEPOS study
Titre de la conférence
From neurobiology to public policy. Abstracts of the 8th International Conference on Early Psychosis: From Neurobiology to Public Policy
Auteur(s)
Conus Philippe, Cotton Sue, Schimmelmann Benno, McGorry Patrick, Lambert Martin
Adresse
Oct 11-13, 2012; San Francisco, CA, United States
ISBN
1751-7893
ISSN-L
1751-7885
Statut éditorial
Publié
Date de publication
2012
Volume
6
Série
Early Intervention in Psychiatry
Pages
35
Langue
anglais
Résumé
There are suggestions that some first-episode psychosis (FEP) patients can have favourable outcome without antipsychotic medication. However, there is very limited data regarding patients' characteristics on which the decision to propose medication free treatment could be based. FEPOS is a fi le-based study of an epidemiological sample of 704 FEP patients treated at EPPIC, Melbourne, between 1998 and 2000. Among the 661 patients where data was available, 108 consistently refused medication during the entire duration of their treatment at EPPIC. In this paper we compared, within this sub-group, patients who had a favourable outcome with those who did not. Patients were aged between 15 and 29 years (M = 21.9, SD = 3.40) and the majority were male (70.4%, n = 76). Symptomatic remission data was available on 105 patients; of these patients 41.0% (n = 41) had achieved remission. Functional remission data was available on 100 patients; of these patients 33.0% (n = 33) had achieved functional remission. Combined remission was evident in 23.0% (n = 23) of patients. Three factors were associated with symptomatic remission: better premorbid functioning (based on GAF, OR = 1.07, p = 0.006), higher number of years of education (OR = 1.43, p = 0.020), and being employed or studying at service entry (OR = 2.59, p = 0.034). Three factors were associated with functional remission: shorter duration of prodrome (OR = 0.50, p = 0.043), severity of psychopathology (CGI-S, OR = 0.51, p = 0.024), and vocational status at service entry (OR = 4.29, p = 0.003). While various aspects of pre-morbid functioning seem to correlate with the possibility of a favourable outcome in FEP patients who refuse medication, various limitations need to be taken into account in this study.
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Création de la notice
12/12/2012 17:34
Dernière modification de la notice
20/08/2019 17:27
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