Resistance of human fungal pathogens to antifungal drugs

Details

Serval ID
serval:BIB_FC977740CCD0
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Resistance of human fungal pathogens to antifungal drugs
Journal
Current Opinion in Microbiology
Author(s)
Sanglard  D.
ISSN
1369-5274 (Print)
Publication state
Published
Issued date
08/2002
Volume
5
Number
4
Pages
379-85
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Aug
Abstract
Resistance mechanisms can be engaged in clinically relevant fungal pathogens under different conditions when exposed to antifungal drugs. Over past years, active research was undertaken in the understanding of the molecular basis of antifungal drug resistance in these pathogens, and especially against the class of azole antifungals. The isolation of various alleles of the gene encoding the target of azoles has enabled correlation of the appearance of resistance with distinct mutations. Resistance mechanisms to azoles also converge to the upregulation of multidrug transporter genes, whose products have the capacity to extrude from cells several chemically unrelated antifungal agents and toxic compounds. Genome-wide studies of azole-resistant isolates are now permitting a more comprehensive analysis of the impact of resistance on gene expression, and may deliver new clues to their mechanisms. Several laboratories are also exploring, as well as possible alternative resistance pathways, the role of biofilm formation by several fungal species in the development of resistance to various antifungals, including azoles.
Keywords
Antifungal Agents/*pharmacology Azoles/*pharmacology Drug Resistance, Fungal/*genetics Fungal Proteins/genetics/metabolism Gene Expression Regulation, Fungal Humans Mitosporic Fungi/*drug effects Mycoses/*microbiology
Pubmed
Web of science
Create date
25/01/2008 14:40
Last modification date
20/08/2019 16:27
Usage data