Modulation pharmacologique des effets tardifs de l'irradiation [Pharmacological modulation of late radio-induced side effects]
Details
Serval ID
serval:BIB_FC8DA0FDD168
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Modulation pharmacologique des effets tardifs de l'irradiation [Pharmacological modulation of late radio-induced side effects]
Journal
Cancer radiotherapie
ISSN
1769-6658 (Electronic)
ISSN-L
1278-3218
Publication state
Published
Issued date
08/2011
Peer-reviewed
Oui
Volume
15
Number
5
Pages
383-389
Language
french
Notes
Publication types: English Abstract ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
After normal tissue exposure to radiation therapy, late side effects can occur and may reduce patients' quality of life due to their progressive nature. Late toxicities occurrence is the main limiting factor of radiotherapy. Various biological disorders related to irradiation are involved in the development of late toxicities including fibrosis. The present review will focus on the recent physiopathological and molecular mechanisms described to be involved in the development of late radio-induced toxicities, that provide therapeutic perspective for pharmacomodulation.
Keywords
Anti-Inflammatory Agents/therapeutic use, Antioxidants/therapeutic use, Clinical Trials, Phase II as Topic, Dose-Response Relationship, Radiation, Epigenesis, Genetic, Extracellular Matrix/drug effects, Extracellular Matrix/radiation effects, Fibroblasts/pathology, Fibroblasts/radiation effects, Fibrosis, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use, Inflammation/drug therapy, Inflammation/etiology, Integrins/physiology, Intercellular Signaling Peptides and Proteins/physiology, Mesoderm/radiation effects, Myoblasts/pathology, Myoblasts/radiation effects, Neoplasm Proteins/physiology, Oxidative Stress, Protein Kinase Inhibitors/therapeutic use, Radiation Injuries/drug therapy, Radiation Injuries/etiology, Radiation Tolerance/genetics, Radiotherapy/adverse effects, Reactive Oxygen Species, Signal Transduction/physiology
Pubmed
Web of science
Create date
30/04/2018 16:09
Last modification date
20/08/2019 17:27
Usage data
