Patients suffering from advanced COPD not only present respiratory symptoms but extrapulmonary manifestations as well: muscle dysfunction, weight loss, osteoporosis, sexual dysfunction, cardiovascular diseases. A chronic inflammation is likely to play a role in the occurrence of these associated disorders. These different aspects contribute to a poor quality of life, and to added morbidity and mortality. The presence of systemic effects in COPD means that the patient suffering from this pulmonary disease needs a comprehensive care.