Developmental status and reconstitution potential of subpopulations of murine thymocytes.

Détails

ID Serval
serval:BIB_FC4B78B8F6E8
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Developmental status and reconstitution potential of subpopulations of murine thymocytes.
Périodique
Immunological Reviews
Auteur(s)
Scollay R., Wilson A., D'Amico A., Kelly K., Egerton M., Pearse M., Wu L., Shortman K.
ISSN
0105-2896 (Print)
ISSN-L
0105-2896
Statut éditorial
Publié
Date de publication
1988
Volume
104
Pages
81-120
Langue
anglais
Résumé
In this chapter we have summarized our view of the subsets of murine CD4- CD8- thymocytes which can be identified with a range of monoclonal antibodies. We have shown the division rate and turnover time of the main subsets and have listed what we know of the TcR gene rearrangement, and expression at the RNA and protein levels. We have been unable to completely segregate gamma delta-TcR-expressing cells from alpha beta-TcR-expressing cells by any of the markers we have used, although the proportions of the two receptor forms vary widely in the different subsets. Experiments involving intrathymic transfer of the CD4- CD8- subsets are described, which indicate that all the TcR- subsets of the CD4- CD8- thymocytes display some precursor activity and which suggest a progression of at least five stages through the TcR- subpopulations of CD4- CD8- cells. The earliest precursor is a Thy 1 low, HSA low, Pgp-1 high cell which has unrearranged C beta and is non-dividing and which closely resembles the bone marrow prothymocyte. The later precursors are Thy 1 high, HSA high, Pgp-1 low, have rearranged C beta and are rapidly dividing. We tentatively conclude that none of the TcR+ CD4- CD8- cells are precursors of the major thymocyte subsets or of typical peripheral T cells, and we have found no evidence so far of separate precursors for the different mature subsets of thymocytes or peripheral T cells.
Mots-clé
Animals, Antigens, Differentiation, T-Lymphocyte, Mice, Mice, Inbred Strains, Phenotype, Stem Cells/classification, Stem Cells/immunology, T-Lymphocytes/classification, T-Lymphocytes/immunology, Thymus Gland/cytology, Thymus Gland/immunology
Pubmed
Web of science
Création de la notice
10/04/2013 12:52
Dernière modification de la notice
20/08/2019 16:27
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