Analytical methods for the quantitative determination of selective serotonin reuptake inhibitors for therapeutic drug monitoring purposes in patients.

Détails

ID Serval
serval:BIB_FB1A5F818C7D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Analytical methods for the quantitative determination of selective serotonin reuptake inhibitors for therapeutic drug monitoring purposes in patients.
Périodique
Journal of Chromatography. B, Biomedical Applications
Auteur(s)
Eap C.B., Baumann P.
ISSN
1572-6495 (Print)
ISSN-L
1572-6495
Statut éditorial
Publié
Date de publication
1996
Peer-reviewed
Oui
Volume
686
Numéro
1
Pages
51-63
Langue
anglais
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Résumé
Five selective serotonin reuptake inhibitors (SSRIs) have been introduced recently: citalopram, fluoxetine, fluvoxamine, paroxetine and sertraline. Although no therapeutic window has been defined for SSRIs, in contrast to tricyclic antidepressants, analytical methods for therapeutic drug monitoring of SSRIs are useful in several instances. SSRIs differ widely in their chemical structure and in their metabolism. The fact that some of them have N-demethylated metabolites, which are also SSRIs, requires that methods be available which allow therapeutic drug monitoring of the parent compounds and of these active metabolites. most procedures are based on prepurification of the SSRIs by liquid-liquid extraction before they are submitted to separation by chromatographic procedures (high-performance liquid chromatography, gas chromatography, thin layer chromatography) and detection by various detectors (UV, fluorescence, electrochemical detector, nitrogen-phosphorus detector, mass spectrometry). This literature review shows that most methods allow quantitative determination of SSRIs in plasma, in the lower ng/ml range, and that they are, therefore, suitable for therapeutic drug monitoring purposes of this category of drugs.
Mots-clé
1-Naphthylamine/analogs & derivatives, 1-Naphthylamine/analysis, Chromatography/methods, Citalopram/blood, Citalopram/chemistry, Fluoxetine/blood, Fluoxetine/chemistry, Fluvoxamine/blood, Fluvoxamine/chemistry, Humans, Paroxetine/blood, Paroxetine/chemistry, Serotonin Uptake Inhibitors/blood, Serotonin Uptake Inhibitors/chemistry, Sertraline
Pubmed
Web of science
Création de la notice
01/03/2013 12:28
Dernière modification de la notice
03/03/2018 22:57
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