Endothelin-1 blockade corrects mesenteric hypoperfusion in a porcine low cardiac output model.

Détails

ID Serval
serval:BIB_FB0B3298E17B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Endothelin-1 blockade corrects mesenteric hypoperfusion in a porcine low cardiac output model.
Périodique
Critical Care Medicine
Auteur(s)
Burgener D., Laesser M., Treggiari-Venzi M., Oi Y., Jolliet P., Strasser S., Hadengue A., Aneman A.
ISSN
0090-3493 (Print)
ISSN-L
0090-3493
Statut éditorial
Publié
Date de publication
2001
Peer-reviewed
Oui
Volume
29
Numéro
8
Pages
1615-1620
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
OBJECTIVE: To study the importance of endothelin-1-induced vasoconstriction in a model of acute and maintained low cardiac output, by investigating regional changes within the mesenteric and particularly the intestinal mucosal circulation.
DESIGN: Prospective, controlled animal study.
SETTING: University-affiliated research laboratory.
SUBJECTS: Thirteen fasted, anesthetized, mechanically ventilated landrace pigs.
MEASUREMENTS AND MAIN RESULTS: Cardiac output, portal venous blood flow, renal arterial flow, jejunal mucosal microcirculation by laser Doppler flowmetry, jejunal capnotonometry (Pco2 gap), and jejunal mucosal oxygenation (tPo2) were monitored. Cardiac tamponade was established to reduce portal venous blood flow to a preset end point at two thirds of baseline. Measurements were made at baseline, after 90 mins of cardiac tamponade, and 90 mins after the administration of the combined endothelinA/endothelinB antagonist tezosentan at 1 mg.kg-1.hr-1 during tamponade in seven animals. Six animals served as time controls and received only the vehicle. Cardiac tamponade decreased portal venous blood flow, renal arterial flow, and laser Doppler flowmetry, whereas the Pco2 gap increased. The change in tPo2 failed to gain statistical significance (p =.08). Administration of tezosentan during tamponade restored portal venous blood flow and laser Doppler flowmetry to baseline values, increased tPo2 above baseline, and decreased Pco2 gap. No effect on renal arterial flow was observed. Investigated variables remained unchanged in control animals after induction of cardiac tamponade.
CONCLUSIONS: Endothelin-1 blockade in acute cardiac failure improves mesenteric, but not renal, perfusion, illustrating the regional importance of endothelin-1-induced vasoconstriction. Importantly, endothelin-1 blockade restored mucosal blood flow and oxygenation, which might be particularly interesting considering the implications for maintenance of mucosal barrier integrity in low output states.
Mots-clé
Animals, Blood Gas Analysis, Cardiac Output, Low/metabolism, Endothelin-1/antagonists & inhibitors, Endothelin-1/physiology, Female, Hemodynamics, Hydrogen-Ion Concentration, Male, Oximetry, Perfusion, Pyridines/pharmacology, Receptors, Endothelin/antagonists & inhibitors, Splanchnic Circulation/drug effects, Swine, Tetrazoles/pharmacology, Vasoconstriction/drug effects, Vasodilator Agents/pharmacology
Pubmed
Web of science
Création de la notice
27/06/2013 15:53
Dernière modification de la notice
03/03/2018 22:57
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