Nouvelles approches therapeutiques de l'hypertension arterielle. [New therapeutic approaches to arterial hypertension]

Détails

ID Serval
serval:BIB_FAA218CB3174
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Nouvelles approches therapeutiques de l'hypertension arterielle. [New therapeutic approaches to arterial hypertension]
Périodique
Schweizerische Medizinische Wochenschrift
Auteur(s)
Waeber B., Brunner  H. R.
ISSN
0036-7672
Statut éditorial
Publié
Date de publication
1982
Peer-reviewed
Oui
Volume
112
Numéro
39
Pages
1330-4
Langue
français
Notes
English Abstract
Journal Article
Review
Résumé
Today two largely new approaches are available for the treatment of clinical hypertension. First, captopril, an orally active angiotensin converting enzyme inhibitor, makes possible chronic blockade of the renin-angiotensin system. This compound, given alone or in combination with a diuretic, normalizes the blood pressure of most hypertensive patients. Unfortunately, because captopril may induce serious adverse effects the use of this inhibitor must be restricted to patients with high blood pressure refractory to conventional antihypertensive drugs. Second, compounds such as verapamil and nifedipine are capable of producing a marked vasodilating effect by inhibiting the entry of calcium into the vascular smooth muscle cells. However, the role of calcium channel blockers in the treatment of hypertensive disease awaits more precise definition.
Mots-clé
Angiotensin II/antagonists & inhibitorsBenzothiadiazinesCalcium/metabolismCalcium Channel Blockers/therapeutic useCaptopril/administration & dosage/adverse effects/pharmacology/therapeuticuseDiureticsDrug Therapy, CombinationHumansHyperkalemia/chemically inducedHypertension/*drug therapyNifedipine/therapeutic useRenin-Angiotensin System/drug effectsSodium/metabolismSodium Chloride Symporter Inhibitors/therapeutic useVasodilationVerapamil/therapeutic use
Pubmed
Web of science
Création de la notice
06/03/2009 13:01
Dernière modification de la notice
03/03/2018 22:56
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