Complete but curtailed T-cell response to very low-affinity antigen.

Détails

ID Serval
serval:BIB_FA90E66DD425
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Complete but curtailed T-cell response to very low-affinity antigen.
Périodique
Nature
Auteur(s)
Zehn D., Lee S.Y., Bevan M.J.
ISSN
1476-4687 (Electronic)
ISSN-L
0028-0836
Statut éditorial
Publié
Date de publication
2009
Volume
458
Numéro
7235
Pages
211-214
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
After an infection, T cells that carry the CD8 marker are activated and undergo a characteristic kinetic sequence of rapid expansion, subsequent contraction and formation of memory cells. The pool of naive T-cell clones is diverse and contains cells bearing T-cell antigen receptors (TCRs) that differ in their affinity for the same antigen. How these differences in affinity affect the function and the response kinetics of individual T-cell clones was previously unknown. Here we show that during the in vivo response to microbial infection, even very weak TCR-ligand interactions are sufficient to activate naive T cells, induce rapid initial proliferation and generate effector and memory cells. The strength of the TCR-ligand interaction critically affects when expansion stops, when the cells exit lymphoid organs and when contraction begins; that is, strongly stimulated T cells contract and exit lymphoid organs later than weakly stimulated cells. Our data challenge the prevailing view that strong TCR ligation is a prerequisite for CD8(+) T-cell activation. Instead, very weak interactions are sufficient for activation, but strong TCR ligation is required to sustain T-cell expansion. We propose that in response to microbial challenge, T-cell clones with a broad range of avidities for foreign ligands are initially recruited, and that the pool of T cells subsequently matures in affinity owing to the more prolonged expansion of high-affinity T-cell clones.
Mots-clé
Animals, Antibody Affinity/immunology, Antigens, Bacterial/immunology, CD8-Positive T-Lymphocytes/immunology, Cell Movement/immunology, Immunologic Memory/immunology, Ligands, Listeria monocytogenes/immunology, Listeriosis/immunology, Mice, Mice, Inbred C57BL, T-Lymphocytes/immunology
Pubmed
Web of science
Création de la notice
04/03/2013 16:15
Dernière modification de la notice
03/03/2018 22:56
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