Influence of food and antacid administration on fluoride bioavailability from enteric-coated sodium fluoride tablets

Details

Serval ID
serval:BIB_FA4BB99EA3D2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Influence of food and antacid administration on fluoride bioavailability from enteric-coated sodium fluoride tablets
Journal
Bone
Author(s)
Arnold  P., Wermeille  M., Chapuy  M. C., Biollaz  J., Grandjean  E. M., Schelling  J. L., Meunier  P. J.
ISSN
8756-3282 (Print)
Publication state
Published
Issued date
1989
Volume
10
Number
6
Pages
401-7
Notes
Journal Article
Abstract
The relative bioavailability of enteric-coated sodium fluoride (NaF) tablets (10 mg F-) has been assessed following administration with a standard calcium-rich breakfast or calcium-poor lunch, and 2 h before or simultaneously with antacid administration (2.4 g aluminum-magnesium hydroxide), versus intake on an empty stomach. Twelve volunteers were studied 3 times according to an open, three-way crossover design over a 24 h period at weekly intervals. Meals were found to decrease the peak serum concentration of NaF from 122 micrograms/L during fasting (after baseline subtraction) to 71 and 88 micrograms/L with breakfast and lunch respectively, and to slow its absorption rate with Tmax increasing from 3.3 to 7.3 and 11.2 hours, without altering its bioavailability. Antacid impaired the bioavailability of NaF by 80% when administered simultaneously, with AUC decreasing from 987 to 155 micrograms.h/L, but had no significant effect when taken 2 h before NaF. In conclusion, the enteric-coated NaF tablets used in this study can be administered with food or after a 2-hour delay following antacid administration, but should not be taken simultaneously with antacid.
Keywords
Adult Aluminum Hydroxide/*pharmacology Biological Availability Calcium/*pharmacology Drug Combinations/pharmacology Female Fluorides/*pharmacokinetics Food Humans Intestinal Absorption/drug effects Magnesium/*pharmacology Magnesium Hydroxide/*pharmacology Male Sodium Fluoride/pharmacokinetics Tablets, Enteric-Coated Urine
Pubmed
Web of science
Create date
25/01/2008 10:40
Last modification date
20/08/2019 16:25
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