Mechanisms by which dopamine alters blood flow distribution during lobar collapse in dogs

Détails

ID Serval
serval:BIB_FA3AEBD1C9A6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Mechanisms by which dopamine alters blood flow distribution during lobar collapse in dogs
Périodique
Journal of Applied Physiology
Auteur(s)
Gardaz  J. P., McFarlane  P. A., Sykes  M. K.
ISSN
8750-7587 (Print)
Statut éditorial
Publié
Date de publication
03/1986
Volume
60
Numéro
3
Pages
959-64
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar
Résumé
Dopamine increases blood flow to a hypoxic left lower lobe in dogs. To elucidate possible mechanisms, left lower lobe collapse was induced in anesthetized dogs, and lobar (QLLL) and total (QT) pulmonary blood flow was measured by electromagnetic flow probes. Dopamine infusion increased mean pulmonary arterial pressure (Ppa), QT, and QLLL. However, the increase in QLLL was double that produced by a similar increase in Ppa without increase in QT (inflation of a Swan-Ganz balloon in right pulmonary artery) or by a similar increase in QT with smaller increase in Ppa (opening of arteriovenous fistulas). QLLL/QT was not changed by opening arteriovenous fistulas, but was increased by Swan-Ganz balloon inflation, and by infusion of dopamine. It is concluded that the increase in QLLL/QT produced by dopamine was due to a decrease in hypoxic vasoconstriction in the lobe secondary to an increase in mixed venous PO2 and to vasoconstriction in the oxygenated lung.
Mots-clé
Animals Atelectasis/blood/*physiopathology Biomechanics Blood Pressure/drug effects Dogs Dopamine/*pharmacology Oxygen/blood Partial Pressure Physiology/instrumentation Pulmonary Circulation/*drug effects
Pubmed
Web of science
Création de la notice
28/01/2008 11:48
Dernière modification de la notice
03/03/2018 22:55
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