IRF-3 partners Bax in a viral-induced dance macabre.
Details
Serval ID
serval:BIB_F9B90978C7AF
Type
Article: article from journal or magazin.
Publication sub-type
Letter (letter): Communication to the publisher.
Collection
Publications
Institution
Title
IRF-3 partners Bax in a viral-induced dance macabre.
Journal
EMBO Journal
ISSN
1460-2075[electronic], 0261-4189[linking]
Publication state
Published
Issued date
2010
Volume
29
Number
10
Pages
1627-1628
Language
english
Abstract
In this issue of The EMBO Journal, Chattopadhyay et al (2010) describe a surprising new mechanism for how viral dsRNA detection by the RIG-I/MAVS signalling complex can initiate apoptosis. Independent of its transcriptional function, a pool of interferon regulatory factor (IRF)-3 activated downstream of MAVS can bind to and activate cytosolic Bax, resulting in Bax translocation to the mitochondria and initiation of the intrinsic apoptotic pathway.
Keywords
Apoptosis, Caspase 8/metabolism, Cytosol/metabolism, Cytosol/virology, DNA, Viral/genetics, Gene Expression Regulation, Gene Expression Regulation, Viral, Humans, Interferon Regulatory Factor-3/metabolism, Mitochondria/metabolism, Mitochondria/virology, Models, Biological, RNA, Double-Stranded/genetics, Transcription, Genetic, Viral Proteins/genetics, bcl-2-Associated X Protein/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
07/09/2010 16:23
Last modification date
20/08/2019 17:25
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