Genetic predictors of adverse radiotherapy effects: the Gene-PARE project

Détails

ID Serval
serval:BIB_F8E9BF0EFFA7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Genetic predictors of adverse radiotherapy effects: the Gene-PARE project
Périodique
International Journal of Radiation Oncology, Biology, Physics
Auteur(s)
Ho  A. Y., Atencio  D. P., Peters  S., Stock  R. G., Formenti  S. C., Cesaretti  J. A., Green  S., Haffty  B., Drumea  K., Leitzin  L., Kuten  A., Azria  D., Ozsahin  M., Overgaard  J., Andreassen  C. N., Trop  C. S., Park  J., Rosenstein  B. S.
ISSN
0360-3016
Statut éditorial
Publié
Date de publication
07/2006
Peer-reviewed
Oui
Volume
65
Numéro
3
Pages
646-55
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Jul 1
Résumé
PURPOSE: The development of adverse effects resulting from the radiotherapy of cancer limits the use of this treatment modality. The validation of a test capable of predicting which patients would be most likely to develop adverse responses to radiation treatment, based on the possession of specific genetic variants, would therefore be of value. The purpose of the Genetic Predictors of Adverse Radiotherapy Effects (Gene-PARE) project is to help achieve this goal. METHODS AND MATERIALS: A continuously expanding biorepository has been created consisting of frozen lymphocytes and DNA isolated from patients treated with radiotherapy. In conjunction with this biorepository, a database is maintained with detailed clinical information pertaining to diagnosis, treatment, and outcome. The DNA samples are screened using denaturing high performance liquid chromatography (DHPLC) and the Surveyor nuclease assay for variants in ATM, TGFB1, XRCC1, XRCC3, SOD2, and hHR21. It is anticipated that additional genes that control the biologic response to radiation will be screened in future work. RESULTS: Evidence has been obtained that possession of variants in genes, the products of which play a role in radiation response, is predictive for the development of adverse effects after radiotherapy. CONCLUSIONS: It is anticipated that the Gene-PARE project will yield information that will allow radiation oncologists to use genetic data to optimize treatment on an individual basis.
Mots-clé
Cell Cycle Proteins/genetics Chromatography, High Pressure Liquid/methods DNA-Binding Proteins/genetics Deoxyribonuclease I/analysis Humans Mutation/genetics Neoplasms/radiotherapy Nuclear Proteins/genetics Phosphoproteins/genetics Polymorphism, Single Nucleotide/*genetics Predictive Value of Tests Protein-Serine-Threonine Kinases/genetics Radiation Injuries/*genetics Radiation Tolerance/*genetics Radiotherapy/*adverse effects Superoxide Dismutase/genetics Transforming Growth Factor beta/genetics Transforming Growth Factor beta1 Tumor Suppressor Proteins/genetics
Pubmed
Web of science
Création de la notice
24/01/2008 18:16
Dernière modification de la notice
03/03/2018 22:53
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