Simultaneous measurement of regional cerebral blood flow by perfusion CT and stable xenon CT: a validation study.

Détails

ID Serval
serval:BIB_F82D69C0E2C2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Simultaneous measurement of regional cerebral blood flow by perfusion CT and stable xenon CT: a validation study.
Périodique
AJNR. American journal of neuroradiology
Auteur(s)
Wintermark M., Thiran J.P., Maeder P., Schnyder P., Meuli R.
ISSN
0195-6108
Statut éditorial
Publié
Date de publication
2001
Peer-reviewed
Oui
Volume
22
Numéro
5
Pages
905-14
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Validation Studies - Publication Status: ppublish
Résumé
BACKGROUND AND PURPOSE: Knowledge of cerebral blood flow (CBF) alterations in cases of acute stroke could be valuable in the early management of these cases. Among imaging techniques affording evaluation of cerebral perfusion, perfusion CT studies involve sequential acquisition of cerebral CT sections obtained in an axial mode during the IV administration of iodinated contrast material. They are thus very easy to perform in emergency settings. Perfusion CT values of CBF have proved to be accurate in animals, and perfusion CT affords plausible values in humans. The purpose of this study was to validate perfusion CT studies of CBF by comparison with the results provided by stable xenon CT, which have been reported to be accurate, and to evaluate acquisition and processing modalities of CT data, notably the possible deconvolution methods and the selection of the reference artery. METHODS: Twelve stable xenon CT and perfusion CT cerebral examinations were performed within an interval of a few minutes in patients with various cerebrovascular diseases. CBF maps were obtained from perfusion CT data by deconvolution using singular value decomposition and least mean square methods. The CBF were compared with the stable xenon CT results in multiple regions of interest through linear regression analysis and bilateral t tests for matched variables. RESULTS: Linear regression analysis showed good correlation between perfusion CT and stable xenon CT CBF values (singular value decomposition method: R(2) = 0.79, slope = 0.87; least mean square method: R(2) = 0.67, slope = 0.83). Bilateral t tests for matched variables did not identify a significant difference between the two imaging methods (P >.1). Both deconvolution methods were equivalent (P >.1). The choice of the reference artery is a major concern and has a strong influence on the final perfusion CT CBF map. CONCLUSION: Perfusion CT studies of CBF achieved with adequate acquisition parameters and processing lead to accurate and reliable results.
Mots-clé
Adult, Cerebrovascular Circulation, Cerebrovascular Disorders, Encephalitis, Female, Humans, Least-Squares Analysis, Male, Middle Aged, Prospective Studies, Reference Values, Regression Analysis, Tomography, X-Ray Computed, Xenon
Pubmed
Web of science
Création de la notice
11/04/2008 9:23
Dernière modification de la notice
03/03/2018 22:51
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