Whole body protein synthesis and energy expenditure in very low birth weight infants.

Details

Serval ID
serval:BIB_F65B3F45C99B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Whole body protein synthesis and energy expenditure in very low birth weight infants.
Journal
Pediatric Research
Author(s)
Catzeflis C., Schutz Y., Micheli J.L., Welsch C., Arnaud M.J., Jéquier E.
ISSN
0031-3998 (Print)
ISSN-L
0031-3998
Publication state
Published
Issued date
1985
Volume
19
Number
7
Pages
679-687
Language
english
Abstract
The aim of the present work was to study whole body protein synthesis and breakdown, as well as energy metabolism, in very low birth weight premature infants (less than 1500 g) during their rapid growth phase. Ten very low birth weight infants were studied during their first and second months of life. They received a mean energy intake of 114 kcal/kg X day and 3 g protein/kg X day as breast milk or milk formula. The average weight gain was 15 g/kg X day. The apparent energy digestibility was 88%, i.e. 99 kcal/kg X day. Their resting postprandial energy expenditure was 58 kcal/kg X day, indicating that 41 kcal/kg X day was retained. The apparent protein digestibility was 89%, i.e. 2.65 g/kg X day. Their rate of protein oxidation was 0.88 g/kg X day so that protein retention was 1.76 g/kg X day. There was a linear relationship between N retention and N intake (r = 0.78, p less than 0.001). The slope of the regression line indicates a net efficiency of N utilization of 67%. Estimates of body composition from the energy balance, coupled with N balance method, showed that 25% of the gain was fat and 75% was lean tissue. Whole body protein synthesis and breakdown were determined using repeated oral administration of 15N glycine for 60-72 h, and 15N enrichment in urinary urea was measured. Protein synthesis averaged 11.2 g/kg X day and protein breakdown 9.4 g/kg X day. Muscular protein breakdown, as estimated by 3-methylhistidine excretion, contributed to 12% of the total protein breakdown.(ABSTRACT TRUNCATED AT 250 WORDS)
Keywords
Body Weight, Diet, Energy Metabolism, Humans, Infant, Low Birth Weight, Infant, Newborn, Muscle Proteins/metabolism, Nitrogen/metabolism, Protein Biosynthesis, Proteins/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
21/01/2008 13:09
Last modification date
20/08/2019 16:22
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