Determination of dextromoramide by capillary gas chromatography and electron impact mass spectrometry.
Details
Serval ID
serval:BIB_F5735203F986
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Determination of dextromoramide by capillary gas chromatography and electron impact mass spectrometry.
Journal
Journal of Analytical Toxicology
ISSN
0146-4760[print], 0146-4760[linking]
Publication state
Published
Issued date
1990
Volume
14
Number
4
Pages
252-253
Language
english
Abstract
A sensitive and specific quantitative assay for the determination of dextromoramide in human fluids and tissues is described. Dextromoramide and an internal standard, SKF 525 A, are isolated by a basic extraction and back-extraction process. The final extract is separated on a 25-m capillary column B.P. 1 and drugs are detected by selected ion monitoring at m/z 100 and m/z 86 for dextromoramide and the internal standard, respectively. The minimum detectable quantities are 0.5 and 0.3 ng/mL, for dextromoramide in plasma and urine, respectively. Coefficients of variation for within-run data were less than 6%.
Keywords
Dextromoramide/blood, Dextromoramide/metabolism, Gas Chromatography-Mass Spectrometry/methods, Humans, Reproducibility of Results
Pubmed
Create date
15/10/2010 16:10
Last modification date
20/08/2019 17:22