CD22-mediated stimulation of T cells regulates T-cell receptor/CD3-induced signaling

Details

Serval ID
serval:BIB_F46840BEB118
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
CD22-mediated stimulation of T cells regulates T-cell receptor/CD3-induced signaling
Journal
Proceedings of the National Academy of Sciences of the United States of America
Author(s)
Aruffo  A., Kanner  S. B., Sgroi  D., Ledbetter  J. A., Stamenkovic  I.
ISSN
0027-8424 (Print)
Publication state
Published
Issued date
1992
Volume
89
Number
21
Pages
10242-10246
Notes
PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S
Abstract
Interaction between B lymphocytes and other cell types is mediated in part by the B-cell adhesion molecule CD22. Recent work has suggested one of the T-cell ligands of B cells to be CD45RO, an isoform of the receptor-linked phosphotyrosine phosphatase CD45. Here we demonstrate direct interaction between CD22 and several isoforms of CD45, including CD45RO, and propose that the interaction may participate in regulation of lymphocyte signaling. Cross-linking of CD3 and CD22 T-cell ligands with anti-CD3 antibody and soluble CD22 is shown to block anti-CD3-induced intracellular calcium increase and to inhibit tyrosine phosphorylation of phospholipase C gamma 1. These effects are consistent with those observed upon coligation of CD3 and CD45 with antibody, providing support to the possibility that ligand-mediated stimulation of CD45 may result in modulation of substrate phosphorylation and lymphocyte activation
Keywords
Antigens,CD/immunology/physiology/Antigens,CD22/Antigens,CD3/Antigens,Differentiation,B-Lymphocyte/Blotting,Western/Calcium/metabolism/Cell Adhesion Molecules/Cell Line/Cells,Cultured/Humans/Lectins/Lymphocyte Activation/Receptors,Antigen,T-Cell/Signal Transduction/T-Lymphocytes/Research
Pubmed
Web of science
Open Access
Yes
Create date
29/01/2008 18:36
Last modification date
20/08/2019 16:21
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