Article: article from journal or magazin.
Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression
Journal Article --- Old month value: Apr
An HIV-1-seropositive volunteer was infused with an expanded autologous cytotoxic T lymphocyte (CTL) clone directed against the HIV-1 nef protein. This clone was adoptively transferred to determine whether supplementing CTL activity could reduce viral load or improve clinical course. Unexpectedly, infusion was followed by a decline in circulating CD4+ T cells and a rise in viral load. Some of the HIV isolates obtained from the plasma or CD4+ cells of the patient were lacking the nef epitope. These results suggest that active CTL selection of viral variants could contribute to the pathogenesis of AIDS and that clinical progression can occur despite high levels of circulating HIV-1-specific CTLs.
Acquired Immunodeficiency Syndrome/immunology/physiopathology/*therapy Amino Acid Sequence Base Sequence CD4 Lymphocyte Count CD4-Positive T-Lymphocytes/immunology CD8-Positive T-Lymphocytes/immunology DNA Primers/chemistry DNA, Viral/analysis Disease Progression Gene Amplification Gene Products, nef/genetics/immunology HIV Antibodies/analysis HIV Core Protein p24/immunology HIV Seropositivity/immunology/physiopathology/therapy HIV-1/*genetics/*immunology/physiology Humans *Immunotherapy, Adoptive Molecular Sequence Data Mutation Nucleic Acid Hybridization T-Lymphocytes, Cytotoxic/*immunology Virus Replication
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