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The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP).
cAMP response element binding protein-2 (CREB-2) is a basic leucine zipper (bZIP) factor that was originally described as a repressor of CRE-dependent transcription but that can also act as a transcriptional activator. Moreover, CREB-2 is able to function in association with the viral Tax protein as an activator of the human T-cell leukemia virus type I (HTLV-I) promoter. Here we show that CREB-2 is able to interact with C/EBP-homologous protein (CHOP), a bZIP transcription factor known to inhibit CAAT/enhancer-dependent transcription. Cotransfection of CHOP with CREB-2 results in decreased activation driven by the cellular CRE motif or the HTLV-I proximal Tax-responsive element, confirming that CREB-2 and CHOP can interact with each other in vivo.
Activating Transcription Factor 4, Animals, CCAAT-Enhancer-Binding Proteins/genetics, CCAAT-Enhancer-Binding Proteins/metabolism, COS Cells, Cell Line, Cell Nucleus/metabolism, Cercopithecus aethiops, Gene Expression Regulation, Viral, Gene Products, tat/metabolism, HIV-1/genetics, Human T-lymphotropic virus 1/genetics, Humans, Leucine Zippers, Promoter Regions, Genetic, Recombinant Fusion Proteins/genetics, Recombinant Fusion Proteins/metabolism, Saccharomyces cerevisiae, Transcription Factor CHOP, Transcription Factors/genetics, Transcription Factors/metabolism, Transcription, Genetic, Two-Hybrid System Techniques, tat Gene Products, Human Immunodeficiency Virus
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