Comprehensive genomic characterization of head and neck squamous cell carcinomas.
Details
Serval ID
serval:BIB_F238B82DF374
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Comprehensive genomic characterization of head and neck squamous cell carcinomas.
Journal
Nature
Working group(s)
Cancer Genome Atlas Network
Contributor(s)
Lawrence M.S., Sougnez C., Lichtenstein L., Cibulskis K., Lander E., Gabriel S.B., Getz G., Ally A., Balasundaram M., Birol I., Bowlby R., Brooks D., Butterfield Y.S., Carlsen R., Cheng D., Chu A., Dhalla N., Guin R., Holt R.A., Jones S.J., Lee D., Li H.I., Marra M.A., Mayo M., Moore R.A., Mungall A.J., Robertson A.G., Schein J.E., Sipahimalani P., Tam A., Thiessen N., Wong T., Protopopov A., Santoso N., Lee S., Parfenov M., Zhang J., Mahadeshwar H.S., Tang J., Ren X., Seth S., Haseley P., Zeng D., Yang L., Xu A.W., Song X., Pantazi A., Bristow C.A., Hadjipanayis A., Seidman J., Chin L., Park P.J., Kucherlapati R., Akbani R., Casasent T., Liu W., Lu Y., Mills G., Motter T., Weinstein J., Diao L., Wang J., Hong Fan Y., Liu J., Wang K., Auman J.T., Balu S., Bodenheimer T., Buda E., Hayes D.N., Hoadley K.A., Hoyle A.P., Jefferys S.R., Jones C.D., Kimes P.K., Liu Y., Marron J.S., Meng S., Mieczkowski P.A., Mose L.E., Parker J.S., Perou C.M., Prins J.F., Roach J., Shi Y., Simons J.V., Singh D., Soloway M.G., Tan D., Veluvolu U., Walter V., Waring S., Wilkerson M.D., Wu J., Zhao N., Cherniack A.D., Hammerman P.S., Tward A.D., Sekhar Pedamallu C., Saksena G., Jung J., Ojesina A.I., Carter S.L., Zack T.I., Schumacher S.E., Beroukhim R., Freeman S.S., Meyerson M., Cho J., Chin L., Getz G., Noble M.S., DiCara D., Zhang H., Heiman D.I., Gehlenborg N., Voet D., Lin P., Frazer S., Stojanov P., Liu Y., Zou L., Kim J., Sougnez C., Gabriel S.B., Lawrence M.S., Muzny D., Doddapaneni H., Kovar C., Reid J., Morton D., Han Y., Hale W., Chao H., Chang K., Drummond J.A., Gibbs R.A., Kakkar N., Wheeler D., Xi L., Ciriello G., Ladanyi M., Lee W., Ramirez R., Sander C., Shen R., Sinha R., Weinhold N., Taylor B.S., Aksoy B.A., Dresdner G., Gao J., Gross B., Jacobsen A., Reva B., Schultz N., Sumer S.O., Sun Y., Chan T.A., Morris L.G., Stuart J., Benz S., Ng S., Benz C., Yau C., Baylin S.B., Cope L., Danilova L., Herman J.G., Bootwalla M., Maglinte D.T., Laird P.W., Triche T., Weisenberger D.J., Van Den Berg D.J., Agrawal N., Bishop J., Boutros P.C., Bruce J.P., Averett Byers L., Califano J., Carey T.E., Chen Z., Cheng H., Chiosea S.I., Cohen E., Diergaarde B., Egloff A.M., El-Naggar A.K., Ferris R.L., Frederick M.J., Grandis J.R., Guo Y., Haddad R.I., Hammerman P.S., Harris T., Hayes D.N., Hui A.B., Lee J.J., Lippman S.M., Liu F.F., McHugh J.B., Myers J., Kwok Shing Ng P., Perez-Ordonez B., Pickering C.R., Prystowsky M., Romkes M., Saleh A.D., Sartor M.A., Seethala R., Seiwert T.Y., Si H., Tward A.D., Van Waes C., Waggott D.M., Wiznerowicz M., Yarbrough W.G., Zhang J., Zuo Z., Burnett K., Crain D., Gardner J., Lau K., Mallery D., Morris S., Paulauskis J., Penny R., Shelton C., Shelton T., Sherman M., Yena P., Black A.D., Bowen J., Frick J., Gastier-Foster J.M., Harper H.A., Leraas K., Lichtenberg T.M., Ramirez N.C., Wise L., Zmuda E., Baboud J., Jensen M.A., Kahn A.B., Pihl T.D., Pot D.A., Srinivasan D., Walton J.S., Wan Y., Burton R.A., Davidsen T., Demchok J.A., Eley G., Ferguson M.L., Mills Shaw K.R., Ozenberger B.A., Sheth M., Sofia H.J., Tarnuzzer R., Wang Z., Yang L., Zenklusen J.C., Saller C., Tarvin K., Chen C., Bollag R., Weinberger P., Golusiński W., Golusiński P., Ibbs M., Korski K., Mackiewicz A., Suchorska W., Szybiak B., Wiznerowicz M., Burnett K., Curley E., Gardner J., Mallery D., Penny R., Shelton T., Yena P., Beard C., Mitchell C., Sandusky G., Agrawal N., Ahn J., Bishop J., Califano J., Khan Z., Bruce J.P., Hui A.B., Irish J., Liu F.F., Perez-Ordonez B., Waldron J., Boutros P.C., Waggott D.M., Myers J., William W.N., Lippman S.M., Egea S., Gomez-Fernandez C., Herbert L., Bradford C.R., Carey T.E., Chepeha D.B., Haddad A.S., Jones T.R., Komarck C.M., Malakh M., McHugh J.B., Moyer J.S., Nguyen A., Peterson L.A., Prince M.E., Rozek L.S., Sartor M.A., Taylor E.G., Walline H.M., Wolf G.T., Boice L., Chera B.S., Funkhouser W.K., Gulley M.L., Hackman T.G., Hayes D.N., Hayward M.C., Huang M., Rathmell W.K., Salazar A.H., Shockley W.W., Shores C.G., Thorne L., Weissler M.C., Wrenn S., Zanation A.M., Chiosea S.I., Diergaarde B., Egloff A.M., Ferris R.L., Romkes M., Seethala R., Brown B.T., Guo Y., Pham M., Yarbrough W.G.
ISSN
1476-4687 (Electronic)
ISSN-L
0028-0836
Publication state
Published
Issued date
29/01/2015
Peer-reviewed
Oui
Volume
517
Number
7536
Pages
576-582
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
The Cancer Genome Atlas profiled 279 head and neck squamous cell carcinomas (HNSCCs) to provide a comprehensive landscape of somatic genomic alterations. Here we show that human-papillomavirus-associated tumours are dominated by helical domain mutations of the oncogene PIK3CA, novel alterations involving loss of TRAF3, and amplification of the cell cycle gene E2F1. Smoking-related HNSCCs demonstrate near universal loss-of-function TP53 mutations and CDKN2A inactivation with frequent copy number alterations including amplification of 3q26/28 and 11q13/22. A subgroup of oral cavity tumours with favourable clinical outcomes displayed infrequent copy number alterations in conjunction with activating mutations of HRAS or PIK3CA, coupled with inactivating mutations of CASP8, NOTCH1 and TP53. Other distinct subgroups contained loss-of-function alterations of the chromatin modifier NSD1, WNT pathway genes AJUBA and FAT1, and activation of oxidative stress factor NFE2L2, mainly in laryngeal tumours. Therapeutic candidate alterations were identified in most HNSCCs.
Keywords
Carcinoma, Squamous Cell/genetics, DNA Copy Number Variations/genetics, DNA, Neoplasm/genetics, Female, Gene Expression Regulation, Neoplastic/genetics, Genome, Human/genetics, Genomics, Head and Neck Neoplasms/genetics, Humans, Male, Molecular Targeted Therapy, Mutation/genetics, Oncogenes/genetics, RNA, Neoplasm/genetics, Signal Transduction/genetics, Transcription Factors/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
13/11/2018 10:20
Last modification date
20/08/2019 17:19
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