Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses

Détails

ID Serval
serval:BIB_F17F18FB5DD3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Increased susceptibility to bacterial superinfection as a consequence of innate antiviral responses
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur(s)
Navarini  A. A., Recher  M., Lang  K. S., Georgiev  P., Meury  S., Bergthaler  A., Flatz  L., Bille  J., Landmann  R., Odermatt  B., Hengartner  H., Zinkernagel  R. M.
ISSN
0027-8424
Statut éditorial
Publié
Date de publication
10/2006
Peer-reviewed
Oui
Volume
103
Numéro
42
Pages
15535-9
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Oct 17
Résumé
The reason why severe localized or systemic virus infections enhance and aggravate bacterial superinfection is poorly understood. Here we show that virus-induced IFN type I caused apoptosis in bone marrow granulocytes, drastically reduced granulocyte infiltrates at the site of bacterial superinfection, caused up to 1,000-fold higher bacterial titers in solid organs, and increased disease susceptibility. The finding that the innate antiviral immune response reduces the antibacterial granulocyte defense offers an explanation for enhanced susceptibility to bacterial superinfection during viral disease.
Mots-clé
Agranulocytosis Animals Apoptosis/physiology Bacterial Infections/*immunology Bone Marrow Cells/cytology/immunology Disease Susceptibility/*immunology Granulocytes/immunology Immunity, Natural/*physiology Interferon Type I/immunology Listeria monocytogenes/immunology/pathogenicity Liver/cytology Lymphocytic Choriomeningitis Lymphocytic choriomeningitis virus/immunology/pathogenicity Mice Mice, Inbred C57BL Mice, Knockout Receptor, Interferon alpha-beta/genetics/metabolism Spleen/cytology Staphylococcus aureus/immunology/pathogenicity Superinfection/*immunology Virus Diseases/*immunology
Pubmed
Web of science
Création de la notice
11/02/2008 13:39
Dernière modification de la notice
03/03/2018 22:38
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