Ultraviolet light exposure, pigmentary traits and the development of melanocytic naevi and cutaneous melanoma. A case-control study of the German Central Malignant Melanoma Registry

Détails

ID Serval
serval:BIB_F152D3C40517
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Ultraviolet light exposure, pigmentary traits and the development of melanocytic naevi and cutaneous melanoma. A case-control study of the German Central Malignant Melanoma Registry
Périodique
Acta Dermato-Venereologica
Auteur(s)
Breitbart  M., Garbe  C., Buttner  P., Weiss  J., Soyer  H. P., Stocker  U., Kruger  S., Breitbart  E. W., Weckbecker  J., Panizzon  R., Bahmer  F., Tilgen  W., Guggenmoos-Holzmann  I., Orfanos  C. E.
ISSN
0001-5555 (Print)
Statut éditorial
Publié
Date de publication
09/1997
Volume
77
Numéro
5
Pages
374-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep
Résumé
The present study firstly aimed at understanding the relationship between sun exposure, pigmentary traits and the history of sunburns. Secondly, the significance of UV-exposure for cutaneous melanoma and for melanocytic naevi was investigated. The case-controlled study comprised 513 patients with primary cutaneous melanoma and 498 controls matched by age and gender. Multivariate logistic regression analysis was used to study melanoma risk factors. The number of common melanocytic naevi was associated with age, gender, the history of sunburns and UV-exposure during holidays (odds-ratio = 1.9; 95% confidence interval = [1.1, 3.4]) for 3 weeks or more. The number of atypical melanocytic naevi was significantly related to age, gender, pigmentary traits, the history of sunburns and UV-exposure during holidays (odds-ratio = 3.5; 95% confidence interval = [1.4, 9.0]) for 2 months or more. The results of the present study showed that both the history of sunburn and intensive sun exposure during holidays were important for the development of melanocytic naevi and, therefore, indirectly for cutaneous melanoma. In addition, a particular type of pigmentation was found to be related to atypical melanocytic naevi.
Mots-clé
Adolescent Adult Case-Control Studies Female Germany/epidemiology Humans Incidence Linear Models Male Melanoma/epidemiology/*etiology Multivariate Analysis Nevus, Pigmented/epidemiology/*etiology Odds Ratio Risk Factors Skin Neoplasms/epidemiology/*etiology Skin Pigmentation/*genetics/physiology Sunburn/*complications Ultraviolet Rays/*adverse effects
Pubmed
Web of science
Création de la notice
25/01/2008 17:55
Dernière modification de la notice
03/03/2018 22:38
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