Hyperacute graft rejection during heart transplantation for giant cell myocarditis: a case report.

Détails

ID Serval
serval:BIB_F0B4388CC516
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Hyperacute graft rejection during heart transplantation for giant cell myocarditis: a case report.
Périodique
Pathology, Research and Practice
Auteur(s)
Mutijima E., Delbecque K., Defraigne J.O., Bouillenne C., Damas P., Pierard L., Boniver J., de Leval L.
ISSN
1618-0631 (Electronic)
ISSN-L
0344-0338
Statut éditorial
Publié
Date de publication
2010
Volume
206
Numéro
6
Pages
411-414
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Résumé
We report the case of a patient with giant cell myocarditis who was bridged to transplantation with mechanical circulatory support and developed a fatal perioperative hyperacute rejection. The patient had received abundant transfusions that had raised her anti-HLA antibody titers. The cross-match test was positive. No pre-transplantation immunosuppressive therapy had been administered given concomitant infection. The severity and acuteness of the rejection in this case likely reflect the combined effect of preformed anti-HLA antibodies in the context of an active organ-specific immune process at the time of transplantation. This case raises the questions of the need for intensive immunosuppressive therapy before transplantation in giant cell myocarditis and of the management of patients with positive cross-match in the context of a giant cell myocarditis.
Mots-clé
Acute Disease, Antibodies/blood, Antibodies/immunology, Blood Grouping and Crossmatching, Fatal Outcome, Female, Giant Cells/pathology, Graft Rejection/immunology, Graft Rejection/pathology, HLA Antigens/immunology, Heart Transplantation/immunology, Heart-Assist Devices, Humans, Middle Aged, Myocarditis/surgery
Pubmed
Création de la notice
22/10/2010 10:49
Dernière modification de la notice
03/03/2018 22:37
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