Age-related changes in Os calcis ultrasonic indices: a 2-year prospective study.

Details

Serval ID
serval:BIB_F0AFB3BCA274
Type
Article: article from journal or magazin.
Collection
Publications
Title
Age-related changes in Os calcis ultrasonic indices: a 2-year prospective study.
Journal
Osteoporosis International
Author(s)
Schott A.M., Hans D., Garnero P., Sornay-Rendu E., Delmas P.D., Meunier P.J.
ISSN
0937-941X
Publication state
Published
Issued date
1995
Peer-reviewed
Oui
Volume
5
Number
6
Pages
478-483
Language
english
Abstract
We performed repeated ultrasound measurements approximately 2 years apart (average 23 months +/- 3 months) on the os calcis of 113 healthy postmenopausal women recruited from two large prospective cohort studies named OFELY and EPIDOS. Group A (from OFELY) consisted of 88 women aged 52-72 (63 +/- 5) years, randomly selected from a large insurance company, and group B (from EPIDOS) consisted of 25 women aged 75-88 (80 +/- 4) years, randomly selected from the voting lists. We obtained broadband ultrasonic attenuation (BUA) and speed of sound (SOS) measurements, as well as the Stiffness index, with a Lunar Achilles ultrasound machine. We performed dual energy X-ray absorptiometry (DXA) measurements of femoral neck bone mineral density (neck BMD) with a Hologic QDR 2000 for group A and with a Lunar DPX Plus for group B. The decrease that we observed over 2 years was on average +/- 1 SD: -1.01 +/- 4.6 dB/MHz (p = 0.02) for BUA (which is approximately equal to the long-term precision error in vitro), -11.3 +/- 9.2 m/s (p = 0.0001) for SOS (approximately 5 times the precision error), -3.8 +/- 4.2% YA (p = 0.0001) for Stiffness (2.5 times the precision error) and -0.01 +/- 0.03 g/cm2 (p = 0.0001) for neck BMD (approximately equal to the precision error). In terms of percentage change this represents: -1.0% +/- 4.3% for BUA, -0.8% +/- 0.6% for SOS and -1.85% +/- 4.4% for neck BMD. At the individual level, most SOS and Stiffness values were consistent with a decrease, whereas BUA and neck BMD values were spread out above and below the zero line of no change. The decreases in SOS and Stiffness were significantly larger in the early postmenopause (< or = 20 years since menopause [YSM]) than in the late postmenopause (> 20 YSM). We observed a similar trend for BUA and BMD but this did not reach statistical significance. We found a weak but significant correlation between changes in ultrasound variables and changes in neck BMD. However, the 2-year changes observed in SOS were not significantly correlated with changes in BUA. This study suggests that the heel ultrasound measurements of SOS and Stiffness are valuable indices of postmenopausal bone loss, and could be used for follow-up in therapeutic trials.
Keywords
Absorptiometry, Photon, Adult, Age Factors, Aged, Aged, 80 and over, Bone Density, Calcaneus, Female, Femur Neck, Humans, Middle Aged, Postmenopause, Prospective Studies, Random Allocation, Time Factors
Pubmed
Web of science
Create date
02/03/2009 12:33
Last modification date
20/08/2019 16:18
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