TPH gene polymorphisms in bipolar patients with and withoutcomorbid social phobia

Détails

ID Serval
serval:BIB_EFE941DC5A05
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Titre
TPH gene polymorphisms in bipolar patients with and withoutcomorbid social phobia
Auteur(s)
Perroud Nader, Baud Patrick, Buresi Catherine, Preisig Martin, Etain Bruno, Bellivier Frank, Favre Sophie, Reber Nadja, Ferrero François, Leboyer Marion, Malafosse Alain
ISBN
1552-4841
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
141B
Série
American journal of medical genetics. Part B, Neuropsychiatric genetics
Pages
745
Langue
anglais
Notes
SAPHIRID:61610
Résumé
Epidemiological and genetic findings suggest comorbid anxiety disorders may help to define more genetically homogeneous forms of bipolar disorder (BD). Recent family-genetic studies suggest that BD with comorbid anxiety disorder constitutes a distinct clinical entity.We have previously shown that social phobia (SP) was linked to a more severe phenotype ofBDwith a higher rate of suicide attempts. SP could therefore be a component of this particular genetic subtype of BD and increase the association strength between BD and genes that have already been suspected in that disorder. The serotonin system has been implicated in the etiology of BD. In this study, polymorphisms of tryptophan hydroxylase (TPH) genes 1 and 2 were compared in BD patients with or without SP.
Method: Genotype and allele frequencies of TPH1 polymorphisms (rs7310929, rs211104, rs1800532 and a 50UTR microsatellite) and TPH2 polymorphisms (rs11178997, rs11179000, rs11179001, rs1386496, rs7305115, and rs1487279) were compared in all BD subjects (N¼453), BD subjects with SP (N¼58), without SP (N¼395) and controls (N¼478) using a chi-square test.
Results: TPH1 rs1800532 and 50UTR microsatellite were significantly associated with BD. However, this association was not strengthened by comorbid SP. Haplotype constructions showed that the more common TPH1 haplotpype was significantly associated with BD. However, this association was not influenced by comorbid SP.
Conclusion: Our results support previous findings suggesting association between TPH and BD. However, they did not show that SP could represent a BD genetic subtype preferentially associated with these genes.
Création de la notice
13/03/2008 9:39
Dernière modification de la notice
03/03/2018 22:35
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